Pentapeptide-18
Tyr-D-Ala-Gly-Phe-Leu, an enkephalin-like peptide that dampens nerve signaling to facial muscles; often combined with Argireline in 'Botox-like' creams. Evidence is mostly in-vitro and manufacturer studies.
Cosmetic ingredient; not a drug.
Look it up on Wikipedia1 listing across 1 independently tested vendor, ranked by price per milligram after coupon codes anyone can use. Vendors you can only order from by message are hidden.
Daily price tracking started October 7, 2026; a price-history chart appears here once a few days have been collected.
| Vendor | Trust | Listing | Vials | Price | Per mg | |
|---|---|---|---|---|---|---|
Core Peptides #282 by metascore |
Metascore 70 medium confidenceFinnrick 76%PepIndex 24/100Bought vials 92% of label · 4 testsTitrateLab · PeptideBase · Peptide Critic · PeptideCheckedLab 99.6% pureOnline checkout |
Pentapeptide-18 (Leuphasyl) – 200MG | 1 × 200 mg | $176.00 | $0.880 | Buy |
Mixing a 200 mg vial
What each common amount of bacteriostatic water gives you on a U-100 insulin syringe. Pick a vial size above to change it.
| Water | Strength | Per 10 units (0.1 mL) | Per unit |
|---|---|---|---|
| 1 mL | 200 mg/mL | 20,000 mcg | 2,000 mcg |
| 2 mL | 100 mg/mL | 10,000 mcg | 1,000 mcg |
| 3 mL | 66.667 mg/mL | 6,666.7 mcg | 666.67 mcg |
| 5 mL | 40 mg/mL | 4,000 mcg | 400 mcg |
Published lab results
1 certificate of analysis that vendors publish for Pentapeptide-18. Numbers are only filled in where the document is readable text; image-only COAs are linked without numbers. A vendor's own COA shows one tested sample, not every batch.
| Vendor | Lab | Date | Label | Measured | Purity | Batch | |
|---|---|---|---|---|---|---|---|
Core Peptides |
Vanguard Laboratory | 2026-08-21 | 200 mg | – | 99.56% | C74164 | View |
Discussions elsewhere
Experiences and questions about Pentapeptide-18 on other sites. Treat anecdotes with care.
Pentapeptide-18: questions people ask
What is Pentapeptide-18?
Cosmetic anti-wrinkle peptide (Leuphasyl). Tyr-D-Ala-Gly-Phe-Leu, an enkephalin-like peptide that dampens nerve signaling to facial muscles; often combined with Argireline in 'Botox-like' creams. Evidence is mostly in-vitro and manufacturer studies.
How much does Pentapeptide-18 cost?
The cheapest Pentapeptide-18 from an independently tested vendor is $0.880 per mg (Core Peptides, Pentapeptide-18 (Leuphasyl) – 200MG, $176.00). Across 1 listings from 1 vendors the median is $0.880 per mg.
Where can I buy Pentapeptide-18?
1 vendors tested by Finnrick sell Pentapeptide-18. The cheapest per mg right now: Core Peptides ($0.880). 1 of them publish a lab report (COA) for Pentapeptide-18; compare lab scores and reports in the table above before buying.
Is Pentapeptide-18 FDA approved?
Cosmetic ingredient; not a drug.