Vialox
Pentapeptide-3, which blocks acetylcholine receptors at the nerve-muscle junction to soften expression lines.
Cosmetic ingredient.
Look it up on Wikipedia1 listing across 1 independently tested vendor, ranked by price per milligram after coupon codes anyone can use. Vendors you can only order from by message are hidden.
Daily price tracking started October 7, 2026; a price-history chart appears here once a few days have been collected.
| Vendor | Trust | Listing | Vials | Price | Per mg | |
|---|---|---|---|---|---|---|
Core Peptides #282 by metascore |
Metascore 70 medium confidenceFinnrick 76%PepIndex 24/100Bought vials 92% of label · 4 testsTitrateLab · PeptideBase · Peptide Critic · PeptideCheckedNo report for thisOnline checkout |
Vialox (Pentapeptide-3V) – 200MG | 1 × 200 mg | $176.00 | $0.880 | Buy |
Mixing a 200 mg vial
What each common amount of bacteriostatic water gives you on a U-100 insulin syringe. Pick a vial size above to change it.
| Water | Strength | Per 10 units (0.1 mL) | Per unit |
|---|---|---|---|
| 1 mL | 200 mg/mL | 20,000 mcg | 2,000 mcg |
| 2 mL | 100 mg/mL | 10,000 mcg | 1,000 mcg |
| 3 mL | 66.667 mg/mL | 6,666.7 mcg | 666.67 mcg |
| 5 mL | 40 mg/mL | 4,000 mcg | 400 mcg |
Doses studied in research Animal or lab studies only
What was given to people (or animals) in published studies and official labels, each linked to its source. This is not a recommendation: study products, purity and supervision differ from research-grade vials.
Animal studies: Only computer-modelling and cell-culture studies exist; Vialox (pentapeptide-3, Gly-Pro-Arg-Pro-Ala) showed no cytotoxicity in HaCaT keratinocytes at concentrations up to 1 mg/mL. No animal dosing studies were found.
No human trials of Vialox have been published; cell-culture concentrations do not translate to any topical or human dose. Not to be confused with palmitoyl pentapeptide-3/4 (Matrixyl, pal-KTTKS).
What the research says
Vialox (pentapeptide-3, Gly-Pro-Arg-Pro-Ala) has no published human trials. The only direct studies are two 2026 computer-modelling plus cell-culture papers, and reviews note that 'botox-like' cosmetic peptides rely mainly on laboratory rather than clinical data.
Key papers ? 3
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Integrative In Silico and In Vitro Evaluation of Vialox and Leuphasyl Pentapeptides for Antiaging Applications.Cells / labMolecular docking, molecular dynamics, ADME/toxicity prediction and in vitro cytotoxicity assay of Vialox and Leuphasyl
Docking and molecular-dynamics models suggested Vialox interacts with SIRT-1 (and less with MMPs); it was not cytotoxic to HaCaT skin cells up to 1 mg/mL. No skin-effect measurements in people or animals.
Key resultNeither peptide showed cytotoxicity on HaCaT cells at concentrations up to 1 mg/mL
Study details
- Studied
- Computer models and HaCaT keratinocyte cell line
- Compared with
- Leuphasyl
- Main outcome
- Predicted binding to MMP-1, -8, -13 and SIRT-1; cytotoxicity
- Authors' conclusion
- Docking suggested Vialox preferentially targets SIRT-1 and Leuphasyl MMP-13; the authors consider this mechanistic insight supporting their promise as dermocosmetic agents.
- Limitations
- In silico and cytotoxicity only; no skin-effect measurements in people or animals.
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In Vitro and In Silico Assessment of Anticancer Activity of Venom-Derived and Biomimetic Neurotransmitter Inhibitor Pentapeptides.Cells / labMolecular docking, MM-GBSA, molecular dynamics, ADMET analysis and MTT cell assays of Vialox and Leuphasyl
Computer models predicted binding of Vialox to cancer targets (e.g. EGFR, PI3K), and it was cytotoxic to some cancer cell lines (MDA-MB-231, PC3) in MTT assays; not related to its cosmetic use.
Key resultDocking scores -10.63 to -7.59 kcal/mol; Vialox-EGFR -9.24 kcal/mol and MM-GBSA binding energy -65.29 kcal/mol; most cytotoxic in MDA-MB-231 and PC3 cells
Study details
- Studied
- Computer models and cancer cell lines (including MDA-MB-231 and PC3)
- Compared with
- Leuphasyl
- Main outcome
- Binding to oncogenic targets (EGFR, PI3K) and cytotoxicity
- Authors' conclusion
- The findings suggest both peptides may exhibit selective anticancer effects; ADMET predicted limited oral bioavailability and minimal BBB penetration.
- Limitations
- In silico and cell-line data only; unrelated to Vialox's cosmetic use.
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Peptides in Facial Plastic Surgery: Emerging Applications in Aesthetics and Rejuvenation.No new dataNarrative review for facial plastic surgery practice
Review of cosmetic peptides including neurotransmitter-inhibiting 'botox-like' peptides: most evidence is from in vitro and ex vivo studies, with limited regulatory oversight and few randomized trials.
Study details
- Studied
- Cosmetic and signal peptides including neurotransmitter-inhibiting 'botox-like' peptides
- Main outcome
- Evidence, mechanisms, safety and efficacy of peptides in skincare
- Authors' conclusion
- Most supporting evidence comes from in vitro and ex vivo studies rather than randomized clinical trials, and products have limited regulatory oversight.
- Limitations
- Narrative review with no original data; Vialox not individually assessed in the abstract.
Reported side effects
No human safety or efficacy data for Vialox in the published literature.
✓ positive · ✗ negative · ~ mixed · ? inconclusive, judged on each paper's own main outcome. Grades: A strong human evidence → D little or none. Papers and verdicts are drawn from PubMed, Europe PMC and Russian journals (CyberLeninka); not medical advice.
Discussions elsewhere
Experiences and questions about Vialox on other sites. Treat anecdotes with care.
Vialox: questions people ask
What is Vialox?
Cosmetic anti-wrinkle peptide. Pentapeptide-3, which blocks acetylcholine receptors at the nerve-muscle junction to soften expression lines.
How much does Vialox cost?
The cheapest Vialox from an independently tested vendor is $0.880 per mg (Core Peptides, Vialox (Pentapeptide-3V) – 200MG, $176.00). Across 1 listings from 1 vendors the median is $0.880 per mg.
Where can I buy Vialox?
1 vendors tested by Finnrick sell Vialox. The cheapest per mg right now: Core Peptides ($0.880). 0 of them publish a lab report (COA) for Vialox; compare lab scores and reports in the table above before buying.
Is Vialox FDA approved?
Cosmetic ingredient.
Does Vialox work? What does the research say?
Evidence grade D (little or no evidence), from 3 papers: Only two computer-modelling and cell-culture studies; no animal or human data. Vialox (pentapeptide-3, Gly-Pro-Arg-Pro-Ala) has no published human trials. The only direct studies are two 2026 computer-modelling plus cell-culture papers, and reviews note that 'botox-like' cosmetic peptides rely mainly on laboratory rather than clinical data. See the papers.
What dose of Vialox was used in studies?
Vialox is tested only in animals or cells. Only computer-modelling and cell-culture studies exist; Vialox (pentapeptide-3, Gly-Pro-Arg-Pro-Ala) showed no cytotoxicity in HaCaT keratinocytes at concentrations up to 1 mg/mL. No animal dosing studies were found. These are amounts used in published studies or official labels, not a recommendation.