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Chonluten research

What published studies found for Chonluten: 2 papers, 0 in humans, with sample sizes and key results.

D
Little or no evidence
Why: Only one human cell-line study and one rat tissue-explant screen from the developer's institute; no animal-disease or human data.

Chonluten (Glu-Asp-Gly) is a 'Khavinson peptide' marketed for the bronchi; the evidence is one human cell-line study and one rat tissue-explant proliferation screen from the developer's institute, with no controlled animal-disease or human data.

? 2 inconclusive

No animal or human safety data in the published literature.

US compounding: Not compoundable. Not an FDA-approved drug and not nominated for FDA's 503A bulks list, so US pharmacies can't legally compound it. Status for every peptide.

Browse and filter these papersChonluten prices and vendors

Animal & lab studies

? InconclusiveanimalИнтегративная физиология · 2025Russian-language

Стимулирующее влияние пептидов на органы дыхательной системы крыс

AnimalsEx vivo tissue-explant culture screen of several short peptides

Organotypic cultures of rat lung, bronchial and bronchial-artery tissue (ex vivo): Glu-Asp-Gly (Chonluten) increased the proliferative area index in lung tissue only, not bronchial tissue; developer's institute co-authored, one of several peptides tested.

Studied
Organotypic cultures of rat lung, bronchial and bronchial artery tissue
Compared with
Untreated explants
Main outcome
Proliferative area index of explants
Authors' conclusion
Glu-Asp-Gly raised the proliferative area index in lung tissue culture only; other peptides acted in more tissues. The authors see this as a basis for developing respiratory therapeutics.
Limitations
Explant cultures, no in vivo or human data; co-authors from the developer's institute.
CyberLeninka (Russian)
? Inconclusivein vitroInt J Mol Sci · 2022

Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.

Cells / labIn vitro comparison of five peptides (Epitalon, Vilon, Thymogen, Thymalin, Chonluten)

In a human monocytic leukemia cell line (THP-1), Chonluten and four other Khavinson peptides modulated kinase signaling and reduced LPS-stimulated TNF and IL-6 release and cell adhesion to activated endothelium.

Studied
Human THP-1 monocytic leukemia cell line (and LPS-activated HUVEC endothelial cells)
Compared with
Untreated cells
Main outcome
Proliferative signalling, TNF and IL-6 expression, adhesion to endothelial cells
Authors' conclusion
The authors suggest the Khavinson peptides act as natural inducers of TNF tolerance in monocytes and as anti-inflammatory molecules in macrophages.
Limitations
Cell-line study of five peptides together; not specific to Epitalon.
PubMed 35408963DOIFree full text

Verdicts are judged on each paper's own main outcome; grades run from A (strong human evidence) to D (little or none). Details are read from the abstracts, and figures are reproduced only from openly licensed full texts. Not medical advice.