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Prostamax research

What published studies found for Prostamax: 5 papers, 0 in humans, with sample sizes and key results.

Little or no evidence

Why: Only cell-culture, chromatin biophysics and tissue-explant studies; no animal or human studies of prostate function.

Prostamax (Lys-Glu-Asp-Pro) is a 'peptide bioregulator' marketed for the prostate, but PubMed holds only a few cell-culture and biophysics studies on chromatin in white blood cells from elderly donors and a rat tissue-explant study; there are no studies of prostate function in animals or humans. One added lymphocyte-culture study (2009) reports effects of copper and cadmium on chromatin but not a clear prostamax result.

? 5 inconclusive

No animal or human safety data in the published literature.

US compounding: Not compoundable. Not an FDA-approved drug and not nominated for FDA's 503A bulks list, so US pharmacies can't legally compound it. Status for every peptide.

Browse and filter these papers Prostamax prices and vendors

Animal & lab studies

? Inconclusivein vitroGeorgian Med News · 2012

[Deheterochromatinization of the chromatin in old age induced by oligopeptide bioregulator (Lys-Glu-Asp-Pro)].

Number of donors not stated; cells from individuals aged 75-86In vitro cytogenetic study of Prostamax (Lys-Glu-Asp-Pro) on chromosomes

In lymphocytes from people aged 75-86, Prostamax doubled the sister-chromatid exchange rate (12.0 vs 5.9 per cell) and increased active ribosomal-gene regions, interpreted by the authors as chromatin 'decondensation'.

Key resultSister chromatid exchanges rose to 12.0 +/- 0.28 per cell (5.9 +/- 0.2 in intact cells); Ag-positive NORs rose to 2.5 per cell (0.95 in intact cells)

Studied: Cells from old individuals (75-86 years)
Compared with: Intact (untreated) cells
Main outcome: Sister chromatid exchange, Ag-positive NORs, pericentromeric heterochromatin
Authors' conclusion: The authors interpret the changes as Prostamax decondensing the chromatin during aging and releasing repressed genes, suggesting a protective chromatin-modifying effect.
Limitations: In vitro cell study; interpretation of chromatin changes as beneficial is speculative; no clinical outcome.

PubMed 23221144

? Inconclusivein vitroBull Exp Biol Med · 2004

Effects of short peptides on lymphocyte chromatin in senile subjects.

Number of subjects not stated; leukocytes from subjects aged 75-88In vitro study of five short peptides (Vilon, Epithalon, Livagen, Prostamax, Cortagen) on chromatin

In white blood cells from people aged 75-88, Prostamax and other short peptides activated ribosomal genes and decondensed chromatin.

Studied: Leukocytes from subjects aged 75-88 years
Compared with: Untreated cells
Main outcome: Ribosome gene activity and chromatin condensation
Authors' conclusion: All peptides activated ribosome genes and decondensed chromatin; Epithalon, Livagen and Prostamax decondensed chromosome 1 pericentromeric chromatin.
Limitations: In vitro; not specific to Prostamax; no clinical outcome.

PubMed 15085253 DOI

? Inconclusivein vitroBiofizika · 2004

[The influence of the peptide bioregulator prostamax on heterochromatin of human lymphocytes in situ].

Cells / labCalorimetric (denaturation) study of lymphocyte chromatin treated with Prostamax

Calorimetry of human lymphocytes showed Prostamax caused small shifts in chromatin denaturation, suggested to reflect partial relaxation of chromatin fibres.

Key resultProstamax shifted endotherms Td III and Td IV to lower temperatures by 2.9 and 1.0 degrees C

Studied: Human lymphocytes
Compared with: Untreated lymphocytes
Main outcome: Chromatin denaturation endotherms
Authors' conclusion: The authors suppose the changes reflect partial relaxation of the 30-nm fiber and small structural changes in nucleosomal organization.
Limitations: In vitro biophysical study; interpretation is speculative.

PubMed 15612551

? Inconclusivein vitroAdv Gerontol · 2006

[The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats].

Cells / labOrganotypic tissue culture with cardiogen, bronchogen, prostamax and pancragen at 0.05 ng/ml

In organ-explant cultures from young and old rats, Prostamax (with cardiogen, bronchogen and pancragen) stimulated growth of the matching tissue (prostate).

Studied: Organotypic explants of heart, lung, prostate and pancreas from young (3-week) and aged (18-month) rats
Compared with: Control explants
Main outcome: Tissue-specific explant growth
Authors' conclusion: At 0.05 ng/ml each peptide stimulated growth in its matching tissue culture compared with controls, so the authors suggest the peptides could stimulate reparative processes in ageing tissues.
Limitations: Explant cultures only; no numerical data in the abstract.

PubMed 17152728

? Inconclusivein vitroGeorgian Med News · 2009

Microcalorimetric study of human blood lymphocytes culture at presence of copper, cadmium and prostamax.

Cells / labMicrocalorimetry of chromatin denaturation with prostamax, Cu(II) and Cd(II)

Lymphocyte cultures from elderly donors: study of prostamax alone and with Cu(II)/Cd(II) ions on chromatin; the abstract reports effects of the metal ions (Cu condensed, Cd decondensed heterochromatin) but not the result for prostamax itself.

Studied: Blood lymphocyte cultures from aging people
Main outcome: Thermal stability / heterochromatin condensation
Authors' conclusion: Cu(II) caused additional heterochromatin condensation and Cd(II) caused decondensation and partial denaturation; the abstract does not state the effect of prostamax.
Limitations: Cell study; the prostamax result is not given in the abstract.

PubMed 19359734

Verdicts are judged on each paper's own main outcome; grades run from A (strong human evidence) to D (little or none). Details are read from the abstracts, and figures are reproduced only from openly licensed full texts. Not medical advice.