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Snap-8 research

What published studies found for Snap-8: 2 papers, 2 in humans, with sample sizes and key results.

D
Little or no evidence
Why: Only two small studies of multi-ingredient microneedle patches in which Snap-8's own effect cannot be isolated.

Snap-8 (acetyl octapeptide-3) has essentially no stand-alone published research. The only studies found are two small clinical tests of multi-ingredient microneedle patches that included it alongside other actives, so any effect cannot be attributed to Snap-8 itself.

? 2 inconclusive

No adverse reactions were reported in the two small multi-ingredient patch studies; no stand-alone human safety data exist.

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Human studies

? Inconclusivehuman trialAnn Dermatol · 2024

Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities.

Twenty-four healthy subjects; DA-MNP and placebo MNP applied to left and right eyesComparative clinical study (within-subject, placebo microneedle patch on the other eye)28 days

24 healthy subjects used an overnight microneedle patch containing acetyl octapeptide-3, a vitamin C derivative and cyclic lysophosphatidic acid on one eye area and a hyaluronic acid-only placebo patch on the other: eye wrinkles, TEWL and elasticity improved more with the active patch over 28 days, with no adverse effects; Snap-8's own contribution cannot be isolated.

Studied
Healthy adults with eye wrinkles
Compared with
Placebo microneedle patch (hyaluronic acid only)
Main outcome
Wrinkle improvement, trans-epidermal water loss, skin elasticity and lifting, adverse effects
Authors' conclusion
The dual anti-wrinkle microneedle patch (containing acetyl octapeptide-3 plus other actives) improved eye wrinkles and skin aging versus placebo patch with no safety concern, and may serve as a transdermal delivery solution.
Limitations
Multi-ingredient patch, so effects cannot be attributed to acetyl octapeptide-3 alone.
PubMed 39082657DOIFree full text
? Inconclusivehuman trialJ Cosmet Dermatol · 2020

Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study.

HumansMonocentric clinical trial of hyaluronic acid microneedle patches12 weeks

12-week single-center study of a microneedle patch with acetyl octapeptide-3 plus four other actives in healthy subjects: fine lines/wrinkles decreased 25.8% and hydration rose 15.4% from baseline, without a control group; no skin reactions were reported.

Key resultFine lines/wrinkles decreased 25.8%; skin hydration improved 15.4%; dermal density and thickness increased 14.2% and 12.9%
Studied
Healthy subjects with aged skin
Main outcome
Skin tolerability, fine lines/wrinkles, hydration, dermal density and thickness
Authors' conclusion
The patches were tolerated excellently and improved measurable skin properties; ingredients may act synergistically.
Limitations
Multi-ingredient patch (acetyl octapeptide-3 among several actives); no comparator stated in the abstract.
PubMed 31134751DOI

Verdicts are judged on each paper's own main outcome; grades run from A (strong human evidence) to D (little or none). Details are read from the abstracts, and figures are reproduced only from openly licensed full texts. Not medical advice.