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Testagen research

What published studies found for Testagen: 6 papers, 0 in humans, with sample sizes and key results, plus 1 registered clinical trials.

C
Mostly animal studies
Why: No human studies; several experiments in hypophysectomized chickens report restored thyroid and thymus structure, plus cell work, from one research group.

Testagen (the tetrapeptide Lys-Glu-Asp-Gly) has no human studies at all in the published literature. The handful of relevant papers are cell-culture and binding work and experiments in hypophysectomized chickens, where the peptide partly restored thyroid and thymus structure.

✓ 4 positive? 2 inconclusive

No human studies and therefore no human safety data in the published literature.

US compounding: Not compoundable. Not an FDA-approved drug and not nominated for FDA's 503A bulks list, so US pharmacies can't legally compound it. Status for every peptide.

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Registered clinical trials

1 trials of Testagen on ClinicalTrials.gov: 1 active, 0 completed. Registered trials include ones that haven't published yet.

TrialStatusPhasePeopleSponsor
Product Transference Study of Testagen™ TDS®-TestosteroneNCT02733133 · started 2027-01-05Not yet recruitingPhase 296Transdermal Delivery Solutions Corp

All 1 Testagen trials, with countries and recruiting status

Animal & lab studies

✓ PositiveanimalBull Exp Biol Med · 2011

Effects of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on hormonal activity and structure of the thyroid gland in hypophysectomized young chickens and old hens.

AnimalsPeptide administration after hypophysectomy40 days

In hypophysectomized young chickens and old hens, 40 days of Lys-Glu-Asp-Gly reduced hormonal and structural thyroid changes, with a weaker normalizing effect in old hens than in chicks.

Studied
Hypophysectomized 5-day-old chickens and old hens
Compared with
Hypophysectomized birds (untreated)
Main outcome
Thyroid hormone concentrations and thyroid structure
Authors' conclusion
Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly significantly reduced hormonal disturbances and structural changes of the thyroid; the normalizing effect was less pronounced in old hens than in chickens.
Limitations
Bird hypophysectomy model; sample size not stated in abstract.
PubMed 22268052DOI
✓ PositiveanimalBull Exp Biol Med · 2013

Effect of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the morphology of the thymus in hypophysectomized young and old birds.

AnimalsPeptide administration after hypophysectomy

In hypophysectomized chicks of different ages, Lys-Glu-Asp-Gly promoted recovery of thymus morphology and was more effective than the related Ala-Glu-Asp-Gly peptide.

Studied
Hypophysectomized young and old chicks
Compared with
Hypophysectomized birds; Ala-Glu-Asp-Gly vs Lys-Glu-Asp-Gly
Main outcome
Thymus morphology
Authors' conclusion
Both peptides promoted recovery of thymic structure regardless of age; Lys-Glu-Asp-Gly (anterior pituitary peptide) had a more pronounced effect than Ala-Glu-Asp-Gly.
Limitations
Bird hypophysectomy model; sample size not stated in abstract.
PubMed 23658898DOI
✓ PositiveanimalBull Exp Biol Med · 2008

Effect of tetrapeptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the structure and function of the thyroid gland in neonatally hypophysectomized chickens.

AnimalsPeptide administration40 days

In neonatally hypophysectomized chickens, 40 days of Lys-Glu-Asp-Gly raised thyrotropin and thyroid hormone concentrations and restored thyroid structure.

Studied
Neonatally hypophysectomized chickens
Compared with
Hypophysectomized chickens
Main outcome
Thyrotropic and thyroid hormone concentrations; thyroid structure
Authors' conclusion
The tetrapeptides were followed by increased thyrotropic and thyroid hormone concentrations and recovery of thyroid gland structure.
Limitations
Bird model; sample size not stated in abstract.
PubMed 19024016DOI
✓ PositiveanimalPatol Fiziol Eksp Ter · 2010

[Effects of hypophyseal Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly synthetic peptides on immunity, hemostasis, morphology and functions of the thyroid gland in neonatally hypophysectomized chicken and one-year-old birds].

AnimalsPeptide injection after hypophysectomy

In hypophysectomized chickens and one-year-old birds, Lys-Glu-Asp-Gly prevented thyroid atrophy and the associated immune and coagulation changes.

Studied
Neonatally hypophysectomized chickens and one-year-old birds
Compared with
Hypophysectomized birds
Main outcome
Thyroid morphology, immunity and hemostasis
Authors' conclusion
The anterior (Lys-Glu-Asp-Gly) and posterior (Ala-Glu-Asp-Gly) pituitary peptides prevented atrophic thyroid changes and normalized immune and hemostatic parameters.
Limitations
Bird hypophysectomy model; sample size not stated in abstract.
PubMed 20731122
? Inconclusivein vitroBiochemistry (Mosc) · 2011

Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.

Cells / labFluorescence microscopy and quenching assays

In HeLa cells, fluorescently labelled testagen entered the cytoplasm and nucleus, showing only that the peptide can reach DNA, not that it has any clinical effect.

Studied
HeLa cells and in vitro oligonucleotide/DNA fluorescence assays
Compared with
Other short peptides (epithalon, pinealon, bronchogen)
Main outcome
Peptide cell/nuclear penetration and DNA binding
Authors' conclusion
Short FITC-labeled peptides including testagen penetrated cells and nuclei and showed sequence-specific interaction with oligonucleotides and DNA, which the authors suggest could epigenetically control gene activity.
Limitations
In vitro only; conclusions about gene regulation are speculative.
PubMed 22117547DOI
? Inconclusivein vitroBiochemistry (Mosc) · 2013

Interaction of short peptides with FITC-labeled wheat histones and their complexes with deoxyribooligonucleotides.

No new dataFluorescence quenching binding assays

In a binding study, Lys-Glu-Asp-Gly and related short peptides bound wheat histones at specific sites; a mechanistic observation with no clinical outcome.

Studied
Short peptides and FITC-labeled wheat histones in vitro
Main outcome
Peptide binding to histones and histone-oligonucleotide complexes
Authors' conclusion
Short peptides including Lys-Glu-Asp-Gly bind wheat histones in a site-specific manner; the authors suggest this may be an epigenetic control mechanism in chromatin.
Limitations
Cell-free assay with plant histones; mechanistic suggestion only.
PubMed 23581987DOI

Verdicts are judged on each paper's own main outcome; grades run from A (strong human evidence) to D (little or none). Details are read from the abstracts, and figures are reproduced only from openly licensed full texts. Not medical advice.