Syn-Ake
A small synthetic peptide modeled on temple-viper venom that relaxes the muscle signal behind expression lines.
Cosmetic ingredient.
Look it up on Wikipedia3 listings across 3 independently tested vendors, ranked by price per milligram after coupon codes anyone can use. Vendors you can only order from by message are hidden.
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Daily price tracking started October 7, 2026; a price-history chart appears here once a few days have been collected.
| Vendor | Trust | Listing | Vials | Price | Per mg | |
|---|---|---|---|---|---|---|
Evolve BioPep #134 by metascore · US |
Metascore 74Finnrick 66%Bought vials 103% of label · 11 testsTitrateLab · Peptide CriticNo report for thisOnline checkout |
Raw Syn-AKE 200mg Powder | 1 × 200 mg | $24.99 | $0.125 | Buy |
Atomik Labz Affiliate #85 by metascore · US. Florida, 33411 |
Metascore 77Finnrick 69%Bought vials 112% of label · 44 testsTitrateLab · Peptide CriticNo report for thisOnline checkoutCheck vendor |
SYN-AKE Raw Powder 1g | 1 × 1 g | $130.00 | $0.130 | Buy |
Core Peptides #282 by metascore |
Metascore 70 medium confidenceFinnrick 76%PepIndex 24/100Bought vials 92% of label · 4 testsTitrateLab · PeptideBase · Peptide Critic · PeptideCheckedNo report for thisOnline checkout |
Syn-AKE – 200MG | 1 × 200 mg | $176.00 | $0.880 | Buy |
Mixing a 200 mg vial
What each common amount of bacteriostatic water gives you on a U-100 insulin syringe. Pick a vial size above to change it.
| Water | Strength | Per 10 units (0.1 mL) | Per unit |
|---|---|---|---|
| 1 mL | 200 mg/mL | 20,000 mcg | 2,000 mcg |
| 2 mL | 100 mg/mL | 10,000 mcg | 1,000 mcg |
| 3 mL | 66.667 mg/mL | 6,666.7 mcg | 666.67 mcg |
| 5 mL | 40 mg/mL | 4,000 mcg | 400 mcg |
Doses studied in research Animal or lab studies only
What was given to people (or animals) in published studies and official labels, each linked to its source. This is not a recommendation: study products, purity and supervision differ from research-grade vials.
Animal studies: Studied alone only in computer-modelling and cell-culture work (antioxidant, cytotoxicity and Ames genotoxicity tests); the abstract does not report the concentrations used, and no animal dosing studies were found.
The only clinical studies (two, n = 50 and n = 42, 12 weeks) tested a topical serum combining it with acetyl hexapeptide-8, gluconolactone, niacinamide and kelp extract; the abstract gives no Syn-Ake concentration and its own effect cannot be separated.
What the research says
Syn-Ake (dipeptide diaminobutyroyl benzylamide diacetate), a synthetic mimic of a viper-venom peptide, has almost no published research: one computer-modelling and cell-culture study, and clinical studies of a multi-ingredient serum that also contained argireline, so its own effect cannot be isolated.
Key papers ? 3
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The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies.Humans + animals12 weeks of use (static wrinkles)One ex-vivo study and two clinical studies of the combined serum
A serum with acetyl hexapeptide-8, Syn-Ake, gluconolactone, niacinamide and kelp extract improved static wrinkle scores by 35-69% and dynamic wrinkles by 10-13% over 12 weeks in two clinical studies (n=50 and n=42; p<0.001); no placebo comparison is described and several actives were combined.
Key resultStatic wrinkle clinical scoring improved 35% to 69% for various wrinkle types after 12 weeks, and dynamic wrinkles by 10%-13% (all p < 0.001).
Study details
- Studied
- Ex-vivo skin samples and volunteers in two clinical studies of a multi-peptide serum (acetyl hexapeptide-8 and others)
- Compared with
- Not described in the abstract
- Main outcome
- Anti-aging biomarkers, clinical scoring of wrinkles and skin quality
- Sample
- Clinical study 1: n = 50; study 2: n = 42; plus one ex-vivo skin study
- Authors' conclusion
- The multi-ingredient serum showed significant anti-aging effects on static and dynamic wrinkles and skin quality. Effects cannot be attributed to any single peptide.
- Limitations
- Combination product; no control group described in the abstract.
-
Anti-aging activity of Syn-Ake peptide by in silico approaches and in vitro tests.Cells / labIn silico docking and 50 ns molecular dynamics plus in vitro tests
Docking and molecular-dynamics models predicted binding to MMPs and SIRT1; in the lab Syn-Ake showed concentration-dependent antioxidant (DPPH) activity and was non-cytotoxic and non-mutagenic at the determined safe dose.
Key resultSyn-Ake bound SIRT1 most stably at -9.32 kcal/mol in docking; DPPH radical scavenging increased with concentration.
Study details
- Studied
- Syn-Ake peptide in computer simulations and in vitro assays (cytotoxicity, Ames genotoxicity, DPPH antioxidant)
- Main outcome
- Binding to MMPs and SIRT1, antioxidant activity, safety
- Authors' conclusion
- In silico and in vitro results suggest Syn-Ake may hold promise in anti-aging formulations with a high efficacy and safety profile.
- Limitations
- Computational and in vitro only; no animal or human data.
-
Peptides in Facial Plastic Surgery: Emerging Applications in Aesthetics and Rejuvenation.No new dataNarrative review for facial plastic surgery practice
Review of cosmetic peptides, including neurotransmitter-inhibiting 'botox-like' peptides: most supporting evidence comes from in vitro and ex vivo work rather than randomized clinical trials.
Study details
- Studied
- Cosmetic and signal peptides including neurotransmitter-inhibiting 'botox-like' peptides
- Main outcome
- Evidence, mechanisms, safety and efficacy of peptides in skincare
- Authors' conclusion
- Most supporting evidence comes from in vitro and ex vivo studies rather than randomized clinical trials, and products have limited regulatory oversight.
- Limitations
- Narrative review with no original data; Vialox not individually assessed in the abstract.
Reported side effects
No human adverse-event data are reported in the published abstracts.
✓ positive · ✗ negative · ~ mixed · ? inconclusive, judged on each paper's own main outcome. Grades: A strong human evidence → D little or none. Papers and verdicts are drawn from PubMed, Europe PMC and Russian journals (CyberLeninka); not medical advice.
Discussions elsewhere
Experiences and questions about Syn-Ake on other sites. Treat anecdotes with care.
Syn-Ake: questions people ask
What is Syn-Ake?
Cosmetic anti-wrinkle peptide. A small synthetic peptide modeled on temple-viper venom that relaxes the muscle signal behind expression lines.
How much does Syn-Ake cost?
The cheapest Syn-Ake from an independently tested vendor is $0.125 per mg (Evolve BioPep, Raw Syn-AKE 200mg Powder, $24.99). Across 3 listings from 3 vendors the median is $0.130 per mg.
Where can I buy Syn-Ake?
3 vendors tested by Finnrick sell Syn-Ake. The cheapest per mg right now: Evolve BioPep ($0.125), Atomik Labz ($0.130), Core Peptides ($0.880). 0 of them publish a lab report (COA) for Syn-Ake; compare lab scores and reports in the table above before buying.
How much bacteriostatic water for 200 mg of Syn-Ake?
Adding 2 mL of bacteriostatic water to a 200 mg vial of Syn-Ake gives 100 mg/mL: each 10 units on a U-100 insulin syringe holds 10,000 mcg. With 1 mL it's 200 mg/mL (20,000 mcg per 10 units); with 3 mL, 66.667 mg/mL (6,666.7 mcg per 10 units). More water makes small amounts easier to measure. Mixing charts: 200 mg.
Is Syn-Ake FDA approved?
Cosmetic ingredient.
Does Syn-Ake work? What does the research say?
Evidence grade D (little or no evidence), from 3 papers: Only a computer-modelling and cell study plus uncontrolled studies of a multi-ingredient serum; Syn-Ake's own effect is not isolated. Syn-Ake (dipeptide diaminobutyroyl benzylamide diacetate), a synthetic mimic of a viper-venom peptide, has almost no published research: one computer-modelling and cell-culture study, and clinical studies of a multi-ingredient serum that also contained argireline, so its own effect cannot be isolated. See the papers.
What dose of Syn-Ake was used in studies?
Syn-Ake is tested only in animals or cells. Studied alone only in computer-modelling and cell-culture work (antioxidant, cytotoxicity and Ames genotoxicity tests); the abstract does not report the concentrations used, and no animal dosing studies were found. These are amounts used in published studies or official labels, not a recommendation.