The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies.
Clinical study 1: n = 50; study 2: n = 42; plus one ex-vivo skin studyOne ex-vivo study and two clinical studies of the combined serum12 weeks of use (static wrinkles)
A serum with acetyl hexapeptide-8, Syn-Ake, gluconolactone, niacinamide and kelp extract improved static wrinkle scores by 35-69% and dynamic wrinkles by 10-13% over 12 weeks in two clinical studies (n=50 and n=42; p<0.001); no placebo comparison is described and several actives were combined.
Key resultStatic wrinkle clinical scoring improved 35% to 69% for various wrinkle types after 12 weeks, and dynamic wrinkles by 10%-13% (all p < 0.001).
- Studied
- Ex-vivo skin samples and volunteers in two clinical studies of a multi-peptide serum (acetyl hexapeptide-8 and others)
- Compared with
- Not described in the abstract
- Main outcome
- Anti-aging biomarkers, clinical scoring of wrinkles and skin quality
- Authors' conclusion
- The multi-ingredient serum showed significant anti-aging effects on static and dynamic wrinkles and skin quality. Effects cannot be attributed to any single peptide.
- Limitations
- Combination product; no control group described in the abstract.