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Ovagen research

What published studies found for Ovagen: 2 papers, 0 in humans, with sample sizes and key results.

D
Little or no evidence
Why: Only one rat kidney-injury study and one cell-culture study of the EDL tripeptide; no human data.

'Ovagen' as sold for research is the tripeptide Glu-Asp-Leu (EDL). The evidence found is one renal cell-culture paper and one rat study of kidney injury, with no human data. The name is shared with an unrelated veterinary FSH product, whose livestock studies were excluded because they say nothing about the peptide.

✓ 2 positive

No human data for the Glu-Asp-Leu peptide; the human-relevant literature under this name is veterinary FSH work in livestock.

US compounding: Not compoundable. Not an FDA-approved drug and not nominated for FDA's 503A bulks list, so US pharmacies can't legally compound it. Status for every peptide.

Browse and filter these papersOvagen prices and vendors

Animal & lab studies

✓ PositiveanimalBull Exp Biol Med · 2017

Nephroprotective Effect of EDL Peptide at Acute Injury of Kidneys of Different Genesis.

AnimalsAnimal experimental models

In rats with gentamicin-induced kidney injury or ischemia/reperfusion injury, the EDL peptide prevented oliguria and azotemia, reduced proteinuria and lipid peroxidation and normalised kidney energy supply.

Studied
Rats with gentamicin nephropathy or kidney ischemia/reperfusion injury
Main outcome
Renal function and oxidative-stress markers
Authors' conclusion
EDL peptide had a nephroprotective effect in both models, supporting further study in kidney pathologies.
Limitations
Rat study from the peptide developer's research tradition; no human data.
PubMed 28744634DOI
✓ Positivein vitroAdv Gerontol · 2014

[Tripeptides slow down aging process in renal cell culture].

Cells / labIn vitro study of tripeptides AED and EDL, with DNA-binding models

In ageing renal cell culture, the tripeptides AED and EDL increased proliferation, lowered the senescence markers p16, p21 and p53 and raised SIRT-6.

Studied
Ageing renal cell culture
Compared with
Young vs aged cultures
Main outcome
Proliferation and aging markers p16, p21, p53, SIRT-6
Authors' conclusion
Peptides AED and EDL increased proliferation, decreased aging markers and increased SIRT-6; the authors propose DNA interaction as the cause of changed gene expression.
Limitations
In vitro; DNA interactions are computed models.
PubMed 25946838

Verdicts are judged on each paper's own main outcome; grades run from A (strong human evidence) to D (little or none). Details are read from the abstracts, and figures are reproduced only from openly licensed full texts. Not medical advice.