MOTS-c vs NAD+
MOTS-c: Mitochondria-encoded peptide. NAD+: Coenzyme (not a peptide). Per milligram, NAD+ is cheaper right now (USD 0.330 vs USD 0.006 at the cheapest tested vendor). MOTS-c has stronger published evidence (grade C vs D). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
MOTS-c
A 16-amino-acid peptide made from mitochondrial DNA that acts like an exercise signal, improving insulin sensitivity and metabolism in mice. Human data are early.
- What it is
- Mitochondria-encoded peptide
- Category
- Mitochondria & energy
- Status
- Not approved. Research use only.
- Cheapest
- USD 0.330 per mg (BeiBangAn)
- Median price
- USD 2.50 per mg
- Vendors
- 87 independently tested, 37 with a lab report
- Research
- Grade C: Mostly animal studies (10 papers)
- Studied as
- tested only in animals or cells
NAD+
Nicotinamide adenine dinucleotide is essential for turning food into cellular energy and for DNA repair enzymes; levels fall with age. Injected and IV NAD+ is popular in wellness clinics, but clinical evidence is limited.
- What it is
- Coenzyme (not a peptide)
- Category
- Mitochondria & energy
- Status
- Not an approved drug for these uses.
- Cheapest
- USD 0.006 per mg (Huatai Peptide)
- Median price
- USD 0.075 per mg
- Vendors
- 86 independently tested, 26 with a lab report
- Research
- Grade D: Little or no evidence (3 papers)
- Studied as
- studied in people
- Reported side effects
- Muscle pain, headache, fatigue or sleep disturbance (mostly mild)
Cheapest tested vendors for MOTS-c and NAD+
Lowest price per milligram at up to three independently tested vendors each. Rankings are by price only; open a vendor to see its lab results.
| Peptide | Vendor | Per mg |
|---|---|---|
| MOTS-c | BeiBangAn | USD 0.330 |
| LN Peptides | USD 0.330 | |
| Shenzhen Loga Tech LG LOGA | USD 0.488 | |
| NAD+ | Huatai Peptide | USD 0.006 |
| Mai Peptide | USD 0.011 | |
| BeiBangAn | USD 0.012 |
Questions people ask
What is the difference between MOTS-c and NAD+?
MOTS-c: Mitochondria-encoded peptide. NAD+: Coenzyme (not a peptide). Per milligram, NAD+ is cheaper right now (USD 0.330 vs USD 0.006 at the cheapest tested vendor). MOTS-c has stronger published evidence (grade C vs D). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Which is cheaper, MOTS-c or NAD+?
NAD+ is cheaper per mg: USD 0.330 for MOTS-c vs USD 0.006 for NAD+ at the cheapest independently tested vendor. The median listing is USD 2.50 per mg for MOTS-c and USD 0.075 per mg for NAD+.
Which is easier to find from a tested vendor, MOTS-c or NAD+?
MOTS-c is sold by more independently tested vendors: 87 list MOTS-c (37 publish a lab report for it) and 86 list NAD+ (26 with a lab report).
Which has more published research, MOTS-c or NAD+?
MOTS-c is graded C (mostly animal studies) from 10 papers and NAD+ is graded D (little or no evidence) from 3 papers. Grades count studies of the exact compound only; they describe how much evidence exists, not which one is better.
Are MOTS-c and NAD+ FDA approved?
MOTS-c: Not approved. Research use only. NAD+: Not an approved drug for these uses.