MOTS-c vs SS-31
MOTS-c: Mitochondria-encoded peptide. SS-31: Mitochondria-targeted peptide (elamipretide). Per milligram, MOTS-c is cheaper right now (USD 0.330 vs USD 0.440 at the cheapest tested vendor). SS-31 has stronger published evidence (grade B vs C). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
MOTS-c
A 16-amino-acid peptide made from mitochondrial DNA that acts like an exercise signal, improving insulin sensitivity and metabolism in mice. Human data are early.
- What it is
- Mitochondria-encoded peptide
- Category
- Mitochondria & energy
- Status
- Not approved. Research use only.
- Cheapest
- USD 0.330 per mg (BeiBangAn)
- Median price
- USD 2.50 per mg
- Vendors
- 87 independently tested, 37 with a lab report
- Research
- Grade C: Mostly animal studies (10 papers)
- Studied as
- tested only in animals or cells
SS-31
Binds cardiolipin in the inner mitochondrial membrane and helps stabilize energy production; studied in mitochondrial diseases, heart failure and aging.
- What it is
- Mitochondria-targeted peptide (elamipretide)
- Category
- Mitochondria & energy
- Status
- FDA accelerated approval in 2025 (Forzinity) for Barth syndrome. Research-vendor versions are unregulated.
- Cheapest
- USD 0.440 per mg (BeiBangAn)
- Median price
- USD 1.68 per mg
- Vendors
- 58 independently tested, 19 with a lab report
- Research
- Grade B: Some human evidence (8 papers)
- Studied as
- an approved drug
- Reported side effects
- Injection-site reactions (mostly mild)
Cheapest tested vendors for MOTS-c and SS-31
Lowest price per milligram at up to three independently tested vendors each. Rankings are by price only; open a vendor to see its lab results.
| Peptide | Vendor | Per mg |
|---|---|---|
| MOTS-c | BeiBangAn | USD 0.330 |
| LN Peptides | USD 0.330 | |
| Shenzhen Loga Tech LG LOGA | USD 0.488 | |
| SS-31 | BeiBangAn | USD 0.440 |
| LN Peptides | USD 0.440 | |
| Nantong Guangyuan Chemical GYC | USD 0.490 |
Questions people ask
What is the difference between MOTS-c and SS-31?
MOTS-c: Mitochondria-encoded peptide. SS-31: Mitochondria-targeted peptide (elamipretide). Per milligram, MOTS-c is cheaper right now (USD 0.330 vs USD 0.440 at the cheapest tested vendor). SS-31 has stronger published evidence (grade B vs C). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Which is cheaper, MOTS-c or SS-31?
MOTS-c is cheaper per mg: USD 0.330 for MOTS-c vs USD 0.440 for SS-31 at the cheapest independently tested vendor. The median listing is USD 2.50 per mg for MOTS-c and USD 1.68 per mg for SS-31.
Which is easier to find from a tested vendor, MOTS-c or SS-31?
MOTS-c is sold by more independently tested vendors: 87 list MOTS-c (37 publish a lab report for it) and 58 list SS-31 (19 with a lab report).
Which has more published research, MOTS-c or SS-31?
MOTS-c is graded C (mostly animal studies) from 10 papers and SS-31 is graded B (some human evidence) from 8 papers. Grades count studies of the exact compound only; they describe how much evidence exists, not which one is better.
Are MOTS-c and SS-31 FDA approved?
MOTS-c: Not approved. Research use only. SS-31: FDA accelerated approval in 2025 (Forzinity) for Barth syndrome. Research-vendor versions are unregulated.