Dihexa
A small modified peptide that boosts HGF/c-Met signaling and new synapse formation; improved learning in rodent studies. No human trials.
Not approved. Research use only.
Look it up on Wikipedia10 listings across 5 independently tested vendors, ranked by price per milligram after coupon codes anyone can use. Vendors you can only order from by message are hidden.
Some links here are affiliate links: if you buy through one, this site may earn a commission at no extra cost to you. Prices, rankings and plans are worked out the same way whether or not a vendor pays one.
Removed from Category 2 in April 2026; FDA plans to put it to its compounding advisory committee before the end of February 2027. Until FDA adds it to the 503A bulks list, US pharmacies can't compound it from bulk.
Daily price tracking started October 7, 2026; a price-history chart appears here once a few days have been collected.
| Vendor | Trust | Listing | Vials | Price | Per mg | |
|---|---|---|---|---|---|---|
Shanghai Wibson Biotechnology WBS #263 by metascore · China |
Dihexa 10mg*10vials (China warehouse) [jinjier] | 10 × 10 mg = 100 mg | $130.00 $13.00 per vial |
$1.30 | Buy | |
Shanghai Wibson Biotechnology WBS #263 by metascore · China |
Dihexa 10mg*10vials (US warehouse 01) [jinjier] | 10 × 10 mg = 100 mg | $140.00 $14.00 per vial |
$1.40 | Buy | |
Shanghai Wibson Biotechnology WBS #263 by metascore · China |
Dihexa 10mg*10vials (China warehouse) [wbspeptide.com] | 10 × 10 mg = 100 mg | $170.00 $17.00 per vial |
$1.70 | Buy | |
Qingdao Sigma Chemical QSC #69 by metascore |
Dihexa 10mg | 20-Vial Kit | HGF/MET Nootropic Peptide | High-Dose Cognitive Research | 20 × 10 mg = 200 mg | $510.00 $25.50 per vial |
$2.55 | Buy | |
Qingdao Sigma Chemical QSC #69 by metascore |
Dihexa 10mg | 10-Vial Kit | HGF/MET Nootropic Peptide | High-Dose Cognitive Research | 10 × 10 mg = 100 mg | $280.00 $28.00 per vial |
$2.80 | Buy | |
Qingdao Sigma Chemical QSC #69 by metascore |
Dihexa 5mg | 20-Vial Kit | HGF/MET Nootropic Peptide | Cognitive & Synaptogenic Research | 20 × 5 mg = 100 mg | $390.00 $19.50 per vial |
$3.90 | Buy | |
Royal Peptides Affiliate #8 by metascore · US |
Metascore 86Finnrick 75%Bought vials 107% of label · 34 testsTitrateLabNo report for thisConfirmed with lab: 3 of 3Online checkout |
Dihexa Peptide 10mg Kit 10% off with code |
10 × 10 mg = 100 mg | 10% off with code $42.75 per vial |
$4.28 list $4.75 |
Buy |
Qingdao Sigma Chemical QSC #69 by metascore |
Dihexa 5mg | 10-Vial Kit | HGF/MET Nootropic Peptide | Cognitive & Synaptogenic Research | 10 × 5 mg = 50 mg | $220.00 $22.00 per vial |
$4.40 | Buy | |
Lab Rat Peptide #206 by metascore · US |
Dihexa 10MG | 1 × 10 mg | $55.00 | $5.50 | Buy | |
Modern Aminos Affiliate #125 by metascore · US |
Metascore 75 medium confidenceFinnrick 79%PepIndex 81/100Bought vials 100% of label · 5 testsTitrateLab · PeptideBase · Peptide CriticNo report for thisOnline checkout |
Dihexa 5MG $30 off through this site's link (new customers) |
1 × 5 mg | $94.00 $30 off through this site's link (new customers) |
$18.80 | Buy |
Mixing a 10 mg vial
What each common amount of bacteriostatic water gives you on a U-100 insulin syringe. Pick a vial size above to change it.
| Water | Strength | Per 10 units (0.1 mL) | Per unit |
|---|---|---|---|
| 1 mL | 10 mg/mL | 1,000 mcg | 100 mcg |
| 2 mL | 5 mg/mL | 500 mcg | 50 mcg |
| 3 mL | 3.333 mg/mL | 333.3 mcg | 33.33 mcg |
| 5 mL | 2 mg/mL | 200 mcg | 20 mcg |
Published lab results
4 certificates of analysis that vendors publish for Dihexa. Numbers are only filled in where the document is readable text; image-only COAs are linked without numbers. A vendor's own COA shows one tested sample, not every batch.
| Vendor | Lab | Date | Label | Measured | Purity | Batch | |
|---|---|---|---|---|---|---|---|
Crush Research |
ILS Laboratories | 2026-09-03 | – | – | 99.14% | CR-DHX10MG-0901 | View |
Loti Labs |
Bioviridian | 2026-07-09 | 10 mg | – | – | View (image) | |
Licensed Peptides |
– | – | 10 mg | – | – | View (image) | |
NextechLabs |
Vanguard Laboratory | – | – | – | – | V251008-24 | View (image) |
Doses studied in research Animal or lab studies only
What was given to people (or animals) in published studies and official labels, each linked to its source. This is not a recommendation: study products, purity and supervision differ from research-grade vials.
Animal studies: Rodent studies only: rats received 2-4 mg/kg delivered locally via hydrogel after sciatic nerve injury (PMID 34703584); other mouse and rat studies (oral and injected) do not state doses in their abstracts, and one rat Huntington's-model study found no benefit.
Not an approved drug and no human trials have been published. Doses in animal studies do not translate directly to people.
What the research says
Dihexa (an angiotensin IV-derived HGF/c-Met modulator) has only animal and cell studies; there are no human trials in the candidate literature, and a key mechanistic paper was later retracted. One rodent Huntington's model found no benefit.
Key papers ✓ 4✗ 1~ 1? 1
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Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies.Animalssize not reported32 studies pooledSystematic review of experimental studies
Systematic review of animal studies: in 8 of 9 cognitive-deficit models, angiotensin IV and analogs (including dihexa) improved spatial working memory or passive-avoidance performance.
Key resultIn models of cognitive deficit, eight of nine studies found Ang IV and its analogs (including dihexa) improved spatial working memory and passive avoidance
Study details
- Studied
- Non-human experimental studies of angiotensin IV, angiotensin-(1-7) and analogs (including dihexa)
- Main outcome
- Cognitive performance (avoidance, object recognition, spatial working memory)
- Sample
- 32 experimental studies included (of 450 articles identified)
- Authors' conclusion
- Studies of cognitive impairment show beneficial effects of acute administration of Ang IV and analogs and of AT4R activation; effects are greatest when given intracerebroventricularly near learning or testing.
- Limitations
- Preclinical studies only; dihexa is one of several analogs reviewed.
-
Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents.Animalssize not reportedChemical optimization and testing of stabilized angiotensin IV analogs
Development study: dihexa was orally active, brain-penetrant and reversed memory deficits in scopolamine-treated and aged rats, with increased synaptogenesis.
Study details
- Studied
- Scopolamine-treated and aged rats; hippocampal synaptogenesis assays
- Main outcome
- Metabolic stability, Morris water maze performance, synaptogenesis
- Authors' conclusion
- Dihexa is an orally active, blood-brain-barrier permeant, stabilized analog with antidementia and synaptogenic activity in rats, and may have therapeutic potential in disorders such as Alzheimer's disease.
- Limitations
- Rodent and in vitro data only; sample sizes not given in abstract.
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The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system.Humans + animalsMechanistic study in vitro and in vivo with HGF antagonist and c-Met shRNA
Reported that dihexa's pro-cognitive and synaptogenic effects depend on HGF/c-Met activation in rats; this paper has since been retracted.
Study details
- Studied
- Cell cultures, hippocampal neurons and rats (Morris water maze)
- Main outcome
- HGF binding, c-Met phosphorylation, spinogenesis/synaptogenesis, spatial learning
- Authors' conclusion
- Dihexa binds HGF with high affinity and its procognitive effects depend on HGF/c-Met activation; an HGF antagonist blocked orally delivered dihexa's effect in the water maze.
- Limitations
- Preclinical; sample sizes not given in abstract.
-
AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway.Animalssize not reportedDose-ranging animal study with PI3K inhibitor wortmannin
In APP/PS1 Alzheimer's mice, dihexa improved Morris water maze performance, increased neuron counts and reduced glial activation and inflammatory cytokines.
Study details
- Studied
- APP/PS1 transgenic mice (Alzheimer's model)
- Main outcome
- Morris water maze learning, neuronal markers, neuroinflammation, PI3K/AKT signaling
- Authors' conclusion
- Dihexa restored spatial learning, reduced neuroinflammation and activated PI3K/AKT in APP/PS1 mice, highlighting the brain AngIV/PI3K/AKT axis as a potential AD target.
- Limitations
- Mouse model; sample sizes not given in abstract.
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Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats.AnimalsForty male Wistar rats in three groupsRandomizedSham/vehicle control5 weeksRandomized three-group animal study: vehicle, 3-NP, 3-NP plus PNB-0408 (dihexa)
In rats with 3-NP-induced Huntington's-like disease, dihexa (PNB-0408) did not protect against weight, motor or cognitive deficits.
Study details
- Studied
- Male Wistar rats given 3-nitropropionic acid (Huntington's-like model)
- Compared with
- Vehicle and 3-NP alone
- Main outcome
- Body weight, motor function, cognition, histopathology
- Authors' conclusion
- PNB-0408 did not protect rats from 3-NP-induced deficits; it may not be an efficacious strategy in this model, and other models or approaches need study.
- Limitations
- Single toxin-induced rat model.
-
Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies.Animals10 experimental groups, 6-8 rats per groupSham/vehicle control16 weeksAnimal study of MSC, G-CSF and/or dihexa given locally or systemically
Rat sciatic nerve repair model: motor function improved with stem cells plus dihexa injected into muscle; effects of dihexa alone are not reported as distinct.
Key resultMotor function at 8-16 weeks improved significantly (P < 0.05) with MSC + G-CSF or MSC + Dihexa into gastrocnemius muscle
Study details
- Studied
- Male Lewis rats with sciatic nerve transection-repair
- Compared with
- Vehicle
- Main outcome
- Sensory and motor limb function (walking foot print grades)
- Authors' conclusion
- MSC, G-CSF and dihexa are promising candidates for adjunct therapy to promote limb recovery after nerve repair.
- Limitations
- Benefit seen with combinations in specific delivery routes; small groups.
-
Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure.Animalssize not reportedIn vivo dose-response and inhibitor experiments
In zebrafish larvae, dihexa protected lateral-line hair cells from neomycin and gentamicin toxicity, an effect blocked by an HGF antagonist.
Study details
- Studied
- Larval zebrafish lateral line hair cells exposed to neomycin or gentamicin
- Main outcome
- Hair cell protection from aminoglycoside toxicity
- Authors' conclusion
- Dihexa at 1 μM gave optimal protection, apparently via HGF-mediated intracellular mechanisms, and may hold clinical potential for mitigating chemical ototoxicity.
- Limitations
- Zebrafish larvae; sample sizes not given in abstract.
Reported side effects
No human safety data in the published literature.
✓ positive · ✗ negative · ~ mixed · ? inconclusive, judged on each paper's own main outcome. Grades: A strong human evidence → D little or none. Papers and verdicts are drawn from PubMed, Europe PMC and Russian journals (CyberLeninka); not medical advice.
Discussions elsewhere
Experiences and questions about Dihexa on other sites. Treat anecdotes with care.
Also sold in blends with Dihexa
Dihexa + Noopept (1) · Dihexa + Selank + Semax (2). The order planner uses these automatically when a blend is cheaper than separate vials.
Dihexa: questions people ask
What is Dihexa?
Angiotensin IV derivative. A small modified peptide that boosts HGF/c-Met signaling and new synapse formation; improved learning in rodent studies. No human trials.
How much does Dihexa cost?
The cheapest Dihexa from an independently tested vendor is $1.30 per mg (Shanghai Wibson Biotechnology WBS, Dihexa 10mg*10vials (China warehouse) [jinjier], $130.00). Across 10 listings from 5 vendors the median is $3.90 per mg.
Where can I buy Dihexa?
5 vendors tested by Finnrick sell Dihexa. The cheapest per mg right now: Shanghai Wibson Biotechnology WBS ($1.30), Qingdao Sigma Chemical QSC ($2.55), Royal Peptides ($4.28). 0 of them publish a lab report (COA) for Dihexa; compare lab scores and reports in the table above before buying.
How much bacteriostatic water for 10 mg of Dihexa?
Adding 2 mL of bacteriostatic water to a 10 mg vial of Dihexa gives 5 mg/mL: each 10 units on a U-100 insulin syringe holds 500 mcg. With 1 mL it's 10 mg/mL (1,000 mcg per 10 units); with 3 mL, 3.333 mg/mL (333.3 mcg per 10 units). More water makes small amounts easier to measure. Mixing charts: 5 mg, 10 mg.
Is Dihexa FDA approved?
Not approved. Research use only.
Can Dihexa be compounded in the US?
Removed from Category 2 in April 2026; FDA plans to put it to its compounding advisory committee before the end of February 2027. Until FDA adds it to the 503A bulks list, US pharmacies can't compound it from bulk. Compounding status for every peptide.
Does Dihexa work? What does the research say?
Evidence grade C (mostly animal studies), from 7 papers: No human trials; several rat and mouse studies report cognitive benefit, one was negative and a key mechanistic paper was retracted. Dihexa (an angiotensin IV-derived HGF/c-Met modulator) has only animal and cell studies; there are no human trials in the candidate literature, and a key mechanistic paper was later retracted. One rodent Huntington's model found no benefit. See the papers.
What dose of Dihexa was used in studies?
Dihexa is tested only in animals or cells. Rodent studies only: rats received 2-4 mg/kg delivered locally via hydrogel after sciatic nerve injury (PMID 34703584); other mouse and rat studies (oral and injected) do not state doses in their abstracts, and one rat Huntington's-model study found no benefit. These are amounts used in published studies or official labels, not a recommendation.
Where do people discuss Dihexa? Is there a Dihexa Reddit?
Communities focused on it include r/CognitivePeptides. Experiences shared there aren't evidence, and some allow vendor promotion. All communities.