Humanin
A small peptide encoded in mitochondrial DNA that protects cells from stress and death in lab and animal studies, including brain and heart cells.
Not approved. Research use only.
Look it up on Wikipedia11 listings across 10 independently tested vendors, ranked by price per milligram after coupon codes anyone can use. Vendors you can only order from by message are hidden.
Not an FDA-approved drug and not nominated for FDA's 503A bulks list, so US pharmacies can't legally compound it.
Daily price tracking started October 7, 2026; a price-history chart appears here once a few days have been collected.
| Vendor | Trust | Listing | Vials | Price | Per mg | |
|---|---|---|---|---|---|---|
Andy Peps Studio #64 by metascore · China |
HU10 Humanin 10mg * 10 vials | 10 × 10 mg = 100 mg | $150.00 $15.00 per vial |
$1.50 | Buy | |
Baohua Dongnuo Biotechnology BHD #77 by metascore · China |
HU10 Humanin 10mg * 10 vials | 10 × 10 mg = 100 mg | $150.00 $15.00 per vial |
$1.50 | Buy | |
LN Peptides #254 by metascore · China |
Metascore 71Finnrick 72%Bought vials 99% of label · 39 testsTitrateLabNo report for thisOnline checkout |
HU10 Humanin 10mg * 10 vials | 10 × 10 mg = 100 mg | $150.00 $15.00 per vial |
$1.50 | Buy |
BeiBangAn #28 by metascore · China |
HU10 Humanin 10mg * 10 vials | 10 × 10 mg = 100 mg | $150.00 $15.00 per vial |
$1.50 | Buy | |
Qingdao Sigma Chemical QSC #69 by metascore |
Humanin 10mg | 20-Vial Kit | 200mg Total | Cytoprotective Mitopeptide | 20 × 10 mg = 200 mg | $690.00 $34.50 per vial |
$3.45 | Buy | |
Qingdao Sigma Chemical QSC #69 by metascore |
Humanin 10mg | 10-Vial Kit | 100mg Total | Cytoprotective Mitopeptide | 10 × 10 mg = 100 mg | $370.00 $37.00 per vial |
$3.70 | Buy | |
Bulk Peptide Wholesale #29 by metascore |
Metascore 82 medium confidenceFinnrick 68%Bought vials 103% of label · 7 testsTitrateLab · PeptideBaseNo report for thisOnline checkout |
Humanin 10 mg (10 vials) | 10 × 10 mg = 100 mg | $500.00 $50.00 per vial |
$5.00 | Buy |
Amino Usa #136 by metascore · US |
Metascore 74 medium confidenceFinnrick 32%Bought vials 89% of label · 3 testsTitrateLabLab 99.4% pureAccount needed |
Humanin 10mg | 1 × 10 mg | $85.00 | $8.50 | Buy |
Pure Peptide Labs #53 by metascore · US |
Metascore 79 medium confidenceFinnrick 63%PepIndex 23/100Bought vials 102% of label · 4 testsTitrateLab · PeptideBase · Peptide CriticLab 99.2% pure · 101% of labelOnline checkout |
Humanin 10 mg | 1 × 10 mg | $99.95 | $10.00 | Buy |
Oasis Peptides #232 by metascore |
Metascore 71Finnrick 56%Bought vials 105% of label · 20 testsTitrateLabNo public reportsOnline checkout |
Humanin 10mg | 1 × 10 mg | $121.50 | $12.15 | Buy |
Core Peptides #282 by metascore |
Metascore 70 medium confidenceFinnrick 76%PepIndex 24/100Bought vials 92% of label · 4 testsTitrateLab · PeptideBase · Peptide Critic · PeptideCheckedNo report for thisOnline checkout |
Humanin – 10MG | 1 × 10 mg | $147.00 | $14.70 | Buy |
Mixing a 10 mg vial
What each common amount of bacteriostatic water gives you on a U-100 insulin syringe. Pick a vial size above to change it.
| Water | Strength | Per 10 units (0.1 mL) | Per unit |
|---|---|---|---|
| 1 mL | 10 mg/mL | 1,000 mcg | 100 mcg |
| 2 mL | 5 mg/mL | 500 mcg | 50 mcg |
| 3 mL | 3.333 mg/mL | 333.3 mcg | 33.33 mcg |
| 5 mL | 2 mg/mL | 200 mcg | 20 mcg |
Published lab results
4 certificates of analysis that vendors publish for Humanin. Numbers are only filled in where the document is readable text; image-only COAs are linked without numbers. A vendor's own COA shows one tested sample, not every batch.
| Vendor | Lab | Date | Label | Measured | Purity | Batch | |
|---|---|---|---|---|---|---|---|
Pure Peptide Labs |
Precision Mass Spec | 2026-08-19 | 10 mg | 10.06 mg 101% | 99.2% | HM1315 | View |
Amino Usa |
BioRegen | 2026-07-16 | – | – | 99.36% | 26HUMA10-0002 | View |
Qingdao Sigma Chemical QSCCOA note |
– | 2026-05-18 | 10 mg | – | – | QSC HU10 | View (image) |
UtherCOA note |
Janoshik | 2026-05-06 | 10 mg | 11.18 mg 112% | 97.589% | HUM10-0415 | View |
Doses studied in research Animal or lab studies only
What was given to people (or animals) in published studies and official labels, each linked to its source. This is not a recommendation: study products, purity and supervision differ from research-grade vials.
Animal studies: Mouse studies gave humanin analogues by direct brain injection (intracerebroventricular; e.g. at least 50 pmol of S14G-HN, or 1000 pmol of [Gly14]-humanin) or by intraperitoneal injection of HNG; cell studies report activity in the low-micromolar range.
No human treatment trials of humanin or its analogues have been published; human studies only measure naturally circulating humanin levels. Doses in animal studies do not translate directly to people.
What the research says
Humanin and its potent analogue HNG have protective effects in mouse and cell models of Alzheimer's disease, stroke, diabetes and aging, but no human treatment trials have been published. One mouse study found humanin accelerated breast-cancer growth and blunted chemotherapy.
Key papers ✓ 5✗ 1~ 3? 2
-
The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan.Humans + animalsCombined worm lifespan, mouse treatment (HNG twice weekly) and human circulating-level comparisons
Humanin extended lifespan in worms, and HNG treatment improved metabolic healthspan markers and lowered inflammation in middle-aged mice; centenarians' children had higher circulating humanin (observational).
Study details
- Studied
- C. elegans, humanin transgenic and middle-aged mice, naked mole-rats, and humans (children of centenarians; Alzheimer's disease and MELAS patients)
- Compared with
- Age-matched control subjects (human levels)
- Main outcome
- Lifespan, metabolic healthspan parameters, inflammatory markers, circulating humanin levels
- Authors' conclusion
- Humanin overexpression increased lifespan in C. elegans (daf-16/Foxo dependent), HNG improved metabolic healthspan parameters and reduced inflammatory markers in mice, and humanin levels were higher in children of centenarians; the authors say humanin is linked to improved healthspan and lifespan.
- Limitations
- Mostly animal data; human findings are observational circulating-level comparisons.
-
A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice.Animalssize not reportedIntracerebroventricular S14G-HN vs S14A-HN (neuroprotection-defective mutant)
Brain-injected S14G-humanin prevented amyloid-beta-induced memory impairment in mice.
Key resultAt least 50 pmol S14G-HN (i.c.v.) prevented Abeta-induced impairment of Y-maze working memory; 5 nmol S14A-HN did not
Study details
- Studied
- Mice with Abeta25-35-induced amnesia
- Compared with
- S14A-HN mutant (5 nmol) and Abeta-amnesic controls
- Main outcome
- Y-maze short-term/spatial working memory, water-finding latent learning, cholinergic neuron counts
- Authors' conclusion
- S14G-HN has rescue activity against memory impairment caused by AD-related insults in vivo, apparently via the same intracellular neuroprotective machinery as seen in vitro.
- Limitations
- Mouse study using direct brain injection.
-
Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway.Humans + animalsCell viability assessed 24 h after reperfusionHNG with PI3K/Akt inhibitors (wortmannin, Akti-1/2); intraventricular HNG before MCAO
HNG injected into the brain reduced infarct volume after experimental stroke in mice via PI3K/Akt signalling.
Study details
- Studied
- Cultured mouse primary cortical neurons (oxygen-glucose deprivation) and mice with middle cerebral artery occlusion
- Compared with
- Untreated and inhibitor-treated
- Main outcome
- Cell viability, Akt phosphorylation, infarct volume
- Authors' conclusion
- HNG increased neuronal viability after OGD and decreased infarct volume after MCAO; PI3K/Akt activation appears to mediate HNG's protection against hypoxia/ischemia-reperfusion injury.
- Limitations
- Cell and mouse study; HNG injected into the brain; no numbers in abstract.
-
The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction.Animalssize not reportedHNG treatment vs untreated diabetic mice
In diabetic mice, HNG reduced cardiac hypertrophy and inflammation and improved heart function.
Study details
- Studied
- Streptozotocin-induced diabetic mice
- Compared with
- Untreated STZ diabetic mice
- Main outcome
- Myocardial hypertrophy, echocardiographic heart function, plasma and cardiac TNF-alpha and IL-6, CK-MB, AST, LDH, p38/NF-kB
- Authors' conclusion
- HNG attenuated STZ-induced myocardial hypertrophy, improved heart function and reduced injury markers and inflammatory cytokines, apparently by inhibiting the p38/NF-kB pathway.
- Limitations
- Mouse study; no numbers in abstract.
-
Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer.Humans + animalsTranscriptomic meta-analysis, immunohistochemistry, HN addition/shRNA silencing in cells, systemic HN in tumour-bearing mice
Safety signal: in mice with triple-negative breast cancer, humanin accelerated tumour growth and lung metastasis and weakened chemotherapy's effect.
Study details
- Studied
- Human TNBC biopsies and cell lines; TNBC-bearing mice
- Compared with
- Untreated / chemotherapy
- Main outcome
- Tumour apoptosis, chemotherapy effect, tumour growth and spontaneous lung metastases
- Authors' conclusion
- HN may exert pro-tumoral effects, so caution is needed when using exogenous HN for degenerative diseases; HN blockade could improve chemotherapy efficacy in breast cancer.
- Limitations
- Experimental (cells and mice); no numbers in abstract.
-
Humanin and diabetes mellitus: A review of in vitro and in vivo studies.No new dataNarrative review of in vitro and in vivo studies
Review of in vitro and animal studies suggesting humanin may improve insulin sensitivity and protect beta cells; no clinical trials cited.
Study details
- Authors' conclusion
- It has been suggested that HN increases insulin sensitivity, improves survival of pancreatic beta cells and delays diabetes onset; the review discusses its emerging role as a therapeutic option.
- Limitations
- Narrative review of preclinical studies; no original data.
-
Humanin and Its Pathophysiological Roles in Aging: A Systematic Review.No new dataSystematic review
Systematic review of humanin in aging: possible roles in cardiovascular disease, neurodegeneration and cancer, with mechanisms not yet clarified and further research needed.
Study details
- Sample
- Number of included studies not stated in abstract
- Authors' conclusion
- Humanin appears to be cytoprotective and to contrast age-related conditions such as cardiovascular disease, neurodegeneration and cancer, but the mechanisms are not fully clarified and further research is needed.
- Limitations
- Mechanisms not clarified; abstract gives no study counts.
-
S14G-humanin attenuates renal ischaemia-reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats.Animals48 animalsSham/vehicle control24 h reperfusionFour-group animal study (Sham, I/R, HNG-Sham, HNG-I/R)
In 48 rats with renal ischemia-reperfusion, S14G-humanin restored antioxidant levels, ATP and mitochondrial complex I activity and reduced apoptosis, but did not change blood urea nitrogen or serum creatinine.
Key resultBUN and creatinine were unaffected by HNG; glutathione, SOD, ATP and complex I activity were significantly restored and apoptotic cells reduced vs I/R
Study details
- Studied
- Male Sprague-Dawley rats with 45 min renal artery ligation and 24 h reperfusion
- Compared with
- Untreated I/R rats
- Main outcome
- Kidney function markers, oxidative stress, ATP, apoptosis, STAT3/ERK1/2 signalling
- Sample
- 48 male Sprague-Dawley rats in four groups
- Authors' conclusion
- The authors suggest S14G-humanin attenuates renal I/R injury, potentially via STAT3 and ERK1/2 activation.
- Limitations
- Rat model; standard kidney function markers (BUN, creatinine) did not improve.
-
Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells.Humans + animalsPatient serum followed day 1 to day 7Mouse model plus in vitro studies and a patient serum observation
In mice with LPS-induced septic ARDS, Humanin-G reduced inflammation and lung injury and restored mitochondrial function in lung endothelial cells; in septic ARDS patients, serum humanin rose on day 1 then fell through day 7.
Study details
- Studied
- Septic ARDS patients (serum humanin measured), LPS-treated mice and endothelial cells
- Compared with
- Untreated septic mice/cells
- Main outcome
- Inflammatory markers, lung injury, mitochondrial function
- Authors' conclusion
- The authors concluded HNG confers protective effects on septic lung endothelium, possibly via competition with IL-6 receptor signalling and STAT3 suppression.
- Limitations
- Treatment evidence is from mice and cells; the human data are only serum measurements.
-
Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.Cells / labIn vitro co-treatment with MOTS-c or S14G-humanin
In primary human myotubes exposed to dexamethasone, S14G-humanin preserved myotube size (p<0.001) but not differentiation (fusion index) or E3 ligase expression; MOTS-c did better on every measure.
Key resultMOTS-c preserved myotube area (p<0.001) and fusion index (p=0.02) and blunted MURF1 upregulation (p=0.03) and STAT3 activation (p=0.005) vs dexamethasone alone
Study details
- Studied
- Primary human skeletal myotubes exposed to dexamethasone
- Compared with
- Dexamethasone alone
- Main outcome
- Myotube area, fusion index, MURF1/MAFbx, Akt and STAT3 signalling
- Authors' conclusion
- The authors suggest MOTS-c could be an effective inhibitor of glucocorticoid-induced atrophy in human muscle via selective MURF1 inhibition, enhanced Akt signalling and suppressed STAT3.
- Limitations
- Cultured cells at a high concentration; no in vivo or human administration.
-
Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats.Animalssize not reportedSham/vehicle control1 or 4 weeksSham-controlled animal study with low-dose and high-dose HNG
In retinal-degeneration rats, high-dose Humanin-G for 4 weeks altered retinal gene expression and improved visual acuity on optokinetic testing, but electroretinography showed no difference from sham.
Key resultVisual acuity improved significantly with high-dose HNG; ERG showed no difference vs sham at 4 weeks
Study details
- Studied
- Royal College of Surgeons rats with retinal pigment epithelium dysfunction and retinal degeneration
- Compared with
- Sham saline injection
- Main outcome
- Electroretinography, optokinetic visual acuity, retinal gene expression
- Authors' conclusion
- The authors suggest HNG can modulate gene expression and improve vision, and warrant further studies as a potential treatment.
- Limitations
- Rat model; mixed functional results (ERG unchanged).
Reported side effects
No human safety data in the published literature; a mouse study raised a concern about promoting tumour growth.
✓ positive · ✗ negative · ~ mixed · ? inconclusive, judged on each paper's own main outcome. Grades: A strong human evidence → D little or none. Papers and verdicts are drawn from PubMed, Europe PMC and Russian journals (CyberLeninka); not medical advice.
Discussions elsewhere
Experiences and questions about Humanin on other sites. Treat anecdotes with care.
Humanin: questions people ask
What is Humanin?
Mitochondria-derived peptide. A small peptide encoded in mitochondrial DNA that protects cells from stress and death in lab and animal studies, including brain and heart cells.
How much does Humanin cost?
The cheapest Humanin from an independently tested vendor is $1.50 per mg (Andy Peps Studio, HU10 Humanin 10mg * 10 vials, $150.00). Across 11 listings from 10 vendors the median is $3.70 per mg.
Where can I buy Humanin?
10 vendors tested by Finnrick sell Humanin. The cheapest per mg right now: Andy Peps Studio ($1.50), Baohua Dongnuo Biotechnology BHD ($1.50), LN Peptides ($1.50). 2 of them publish a lab report (COA) for Humanin; compare lab scores and reports in the table above before buying.
How much bacteriostatic water for 10 mg of Humanin?
Adding 2 mL of bacteriostatic water to a 10 mg vial of Humanin gives 5 mg/mL: each 10 units on a U-100 insulin syringe holds 500 mcg. With 1 mL it's 10 mg/mL (1,000 mcg per 10 units); with 3 mL, 3.333 mg/mL (333.3 mcg per 10 units). More water makes small amounts easier to measure. Mixing charts: 10 mg.
Is Humanin FDA approved?
Not approved. Research use only.
Can Humanin be compounded in the US?
Not an FDA-approved drug and not nominated for FDA's 503A bulks list, so US pharmacies can't legally compound it. Compounding status for every peptide.
Does Humanin work? What does the research say?
Evidence grade C (mostly animal studies), from 11 papers: Many mouse and rat studies (Alzheimer's, stroke, diabetes, aging) with mostly protective effects, one showing faster tumour growth; no human trials. Humanin and its potent analogue HNG have protective effects in mouse and cell models of Alzheimer's disease, stroke, diabetes and aging, but no human treatment trials have been published. One mouse study found humanin accelerated breast-cancer growth and blunted chemotherapy. See the papers.
What dose of Humanin was used in studies?
Humanin is tested only in animals or cells. Mouse studies gave humanin analogues by direct brain injection (intracerebroventricular; e.g. at least 50 pmol of S14G-HN, or 1000 pmol of [Gly14]-humanin) or by intraperitoneal injection of HNG; cell studies report activity in the low-micromolar range. These are amounts used in published studies or official labels, not a recommendation.