PNC-27
A fragment of the p53 tumor-suppressor protein joined to a cell-penetrating sequence; in lab studies it punches holes in cancer-cell membranes.
Not approved. Lab research only.
Look it up on Wikipedia27 listings across 21 independently tested vendors, ranked by price per milligram after coupon codes anyone can use. Vendors you can only order from by message are hidden.
Some links here are affiliate links: if you buy through one, this site may earn a commission at no extra cost to you. Prices, rankings and plans are worked out the same way whether or not a vendor pays one.
Not an FDA-approved drug and not nominated for FDA's 503A bulks list, so US pharmacies can't legally compound it.
Daily price tracking started October 7, 2026; a price-history chart appears here once a few days have been collected.
| Vendor | Trust | Listing | Vials | Price | Per mg | |
|---|---|---|---|---|---|---|
Uther #62 by metascore · China |
Metascore 79Finnrick 64%Bought vials 105% of label · 73 testsTitrateLabNo report for thisOnline checkout |
PNC-27 30mg (10 Vials / Kit) | 10 × 30 mg = 300 mg | $270.00 $27.00 per vial |
$0.900 | Buy |
Hangzhou Youngpeptide Biotechnology HYB #153 by metascore |
PNC-27 10 mg – 10 Vials | 10 × 10 mg = 100 mg | $105.00 $10.50 per vial |
$1.05 | Buy | |
Huatai Peptide #15 by metascore · China |
Metascore 85Finnrick 72%Bought vials 97% of label · 12 testsTitrateLabNo report for thisConfirmed with lab: 15 of 15Online checkout |
PNC27 10Bottlex10mg | 10 × 10 mg = 100 mg | $174.00 $17.40 per vial |
$1.74 | Buy |
Mai Peptide #35 by metascore · China |
Metascore 82Finnrick 60%Bought vials 101% of label · 107 testsTitrateLabNo report for thisConfirmed with lab: 26 of 26Online checkout |
PNC-27 10mg*10vials | 10 × 10 mg = 100 mg | $208.00 $20.80 per vial |
$2.08 | Buy |
Qingdao Sigma Chemical QSC #69 by metascore |
PNC-27 10mg | 20-Vial Kit | 100mg Total | Anticancer Peptide | 20 × 10 mg = 200 mg | $550.00 $27.50 per vial |
$2.75 | Buy | |
Mai Peptide #35 by metascore · China |
Metascore 82Finnrick 60%Bought vials 101% of label · 107 testsTitrateLabNo report for thisConfirmed with lab: 26 of 26Online checkout |
PNC-27 5mg*10vials | 10 × 5 mg = 50 mg | $141.00 $14.10 per vial |
$2.82 | Buy |
Qingdao Sigma Chemical QSC #69 by metascore |
PNC-27 10mg | 10-Vial Kit | 100mg Total | Anticancer Peptide | 10 × 10 mg = 100 mg | $300.00 $30.00 per vial |
$3.00 | Buy | |
Qingdao Sigma Chemical QSC #69 by metascore |
PNC-27 5mg | 20-Vial Kit | Anticancer Peptide Kit | 20 × 5 mg = 100 mg | $430.00 $21.50 per vial |
$4.30 | Buy | |
Qingdao Sigma Chemical QSC #69 by metascore |
PNC-27 5mg | 10-Vial Kit | Anticancer Peptide Kit | 10 × 5 mg = 50 mg | $240.00 $24.00 per vial |
$4.80 | Buy | |
Planet Peptide #21 by metascore · US: FL |
Metascore 84Finnrick 65%Bought vials 112% of label · 63 testsTitrateLab · Peptide CriticLab report (image)Online checkout |
PNC-27 30MG | 1 × 30 mg | $150.00 | $5.00 | Buy |
Bulk Peptide Wholesale #29 by metascore |
Metascore 82 medium confidenceFinnrick 68%Bought vials 103% of label · 7 testsTitrateLab · PeptideBaseNo report for thisOnline checkout |
PNC-27 5 mg (10 vials) | 10 × 5 mg = 50 mg | $275.00 $27.50 per vial |
$5.50 | Buy |
Evolve BioPep #134 by metascore · US |
Metascore 74Finnrick 66%Bought vials 103% of label · 11 testsTitrateLab · Peptide CriticNo report for thisOnline checkout |
PNC-27 5mg | 1 × 5 mg | $29.99 | $6.00 | Buy |
Peptagon #31 by metascore |
Metascore 82 medium confidenceFinnrick UnratedBought vials 102% of label · 3 testsTitrateLabNo report for thisConfirmed with lab: 38 of 38Online checkout |
PNC-28 Research Peptide – 20mg | 1 × 20 mg | $165.00 | $8.25 | Buy |
Alpha BioMed #281 by metascore · US |
PNC-28 (20mg) | 1 × 20 mg | $175.00 | $8.75 | Buy | |
Eros Peptides #129 by metascore · US, GA 30339 |
Metascore 74 medium confidenceFinnrick 77%Bought vials 110% of label · 3 testsTitrateLab · Peptide CriticLab report (image)Online checkout |
PNC-27 5MG | 1 × 5 mg | $46.75 | $9.35 | Buy |
Paramount Peptides #133 by metascore · US CA |
Metascore 74Finnrick 64%PepIndex 55/100Bought vials 114% of label · 65 testsTitrateLab · Peptide CriticNo report for thisOnline checkout |
PNC-28 (20mg) | 1 × 20 mg | $191.25 | $9.56 | Buy |
Atomik Labz Affiliate #85 by metascore · US. Florida, 33411 |
Metascore 77Finnrick 69%Bought vials 112% of label · 44 testsTitrateLab · Peptide CriticNo report for thisOnline checkoutCheck vendor |
PNC-27 10mg Ten Pack | 10 × 10 mg = 100 mg | $990.00 $99.00 per vial |
$9.90 | Buy |
Atomik Labz Affiliate #85 by metascore · US. Florida, 33411 |
Metascore 77Finnrick 69%Bought vials 112% of label · 44 testsTitrateLab · Peptide CriticNo report for thisOnline checkoutCheck vendor |
PNC-27 10mg | 1 × 10 mg | $110.00 | $11.00 | Buy |
Liberty Peptides #63 by metascore · US, DE 19801 |
Metascore 79Finnrick 53%Bought vials 107% of label · 18 testsTitrateLab · PeptideBaseLab 99.7% pure · 115% of labelOnline checkout |
PNC-27 (10mg) | 1 × 10 mg | $119.00 | $11.90 | Buy |
Peptidology #5 by metascore · US, AZ 85254 |
Metascore 87Finnrick 71%Bought vials 97% of label · 18 testsTitrateLab · PeptideBase · Peptide Critic · PeptideCheckedNo report for thisConfirmed with lab: 34 of 34Online checkout |
PNC-27 10 mg (10mg) | 1 × 10 mg | $119.99 | $12.00 | Buy |
Coffee and Peppers #14 by metascore |
Metascore 85Finnrick 70%Bought vials 102% of label · 30 testsTitrateLabNo report for thisConfirmed with lab: 6 of 6Online checkout |
PNC-27 5MG | 1 × 5 mg | $64.99 | $13.00 | Buy |
Platinum Cryo #211 by metascore · Akron, OH US |
Metascore 72Finnrick 63%Bought vials 102% of label · 24 testsTitrateLabNo report for thisOnline checkoutCheck vendor |
PNC-27 12MG | 1 × 12 mg | $169.95 | $14.16 | Buy |
Amino Usa #136 by metascore · US |
Metascore 74 medium confidenceFinnrick 32%Bought vials 89% of label · 3 testsTitrateLabNo report for thisAccount needed |
PNC-27 10mg | 1 × 10 mg | $149.99 | $15.00 | Buy |
Platinum Cryo #211 by metascore · Akron, OH US |
Metascore 72Finnrick 63%Bought vials 102% of label · 24 testsTitrateLabNo report for thisOnline checkoutCheck vendor |
PNC-27 6MG | 1 × 6 mg | $109.95 | $18.33 | Buy |
Pure Peptide Labs #53 by metascore · US |
Metascore 79 medium confidenceFinnrick 63%PepIndex 23/100Bought vials 102% of label · 4 testsTitrateLab · PeptideBase · Peptide CriticNo report for thisOnline checkout |
PNC-27 5 mg | 1 × 5 mg | $99.95 | $19.99 | Buy |
Core Peptides #282 by metascore |
Metascore 70 medium confidenceFinnrick 76%PepIndex 24/100Bought vials 92% of label · 4 testsTitrateLab · PeptideBase · Peptide Critic · PeptideCheckedLab 98.3% pureOnline checkout |
PNC-27 – 5MG | 1 × 5 mg | $138.00 | $27.60 | Buy |
Biolongevity Labs #166 by metascore · US, Akron, OH 44321 |
Metascore 73Finnrick 71%PepIndex 58/100Bought vials 102% of label · 34 testsTitrateLab · Peptide CriticNo report for thisOnline checkout |
PNC-27 (10mg) | 1 × 10 mg | $279.97 | $28.00 | Buy |
Mixing a 5 mg vial
What each common amount of bacteriostatic water gives you on a U-100 insulin syringe. Pick a vial size above to change it.
| Water | Strength | Per 10 units (0.1 mL) | Per unit |
|---|---|---|---|
| 1 mL | 5 mg/mL | 500 mcg | 50 mcg |
| 2 mL | 2.5 mg/mL | 250 mcg | 25 mcg |
| 3 mL | 1.667 mg/mL | 166.7 mcg | 16.67 mcg |
| 5 mL | 1 mg/mL | 100 mcg | 10 mcg |
Published lab results
5 certificates of analysis that vendors publish for PNC-27. Numbers are only filled in where the document is readable text; image-only COAs are linked without numbers. A vendor's own COA shows one tested sample, not every batch.
| Vendor | Lab | Date | Label | Measured | Purity | Batch | |
|---|---|---|---|---|---|---|---|
Core Peptides |
Vanguard Laboratory | 2026-08-21 | 5 mg | – | 98.33% | C74166 | View |
Liberty Peptides |
– | 2026-04-01 | 10 mg | 11.47 mg 115% | 99.7% | View | |
GLP Keep Body PeptideCOA concerns 8 of its 11 posted COAs are other parties' tests (Diversified Botanics, Lunar Biotech, a Novaglo-branded vial, Finnrick screenshots); only 3 name GLP Keep Body. It may supply those brands, but nothing on the site shows it. Checked 2026-10-08. How we check |
Freedom Diagnostics | 2025-12-26 | 5 mg | – | – | View (image) | |
Eros PeptidesCOA note |
Freedom Diagnostics | – | 5 mg | – | – | View (image) | |
Planet Peptide |
Freedom Diagnostics | – | 30 mg | – | – | View (image) |
Doses studied in research Animal or lab studies only
What was given to people (or animals) in published studies and official labels, each linked to its source. This is not a recommendation: study products, purity and supervision differ from research-grade vials.
Animal studies: Studied only in cancer cell lines (micromolar concentrations) and a few mouse tumor models; the abstracts do not report mg/kg doses.
No human studies of PNC-27 were found, so no studied human doses exist. Not an approved drug.
What the research says
PNC-27 (a p53-derived HDM-2-binding peptide fused to a penetratin sequence) has been studied only in cancer cell lines and a few mouse tumor models; there are no published human trials. Most of the work comes from a single research group.
Key papers ✓ 8~ 1? 1
-
Targeting cell membrane HDM2: A novel therapeutic approach for acute myeloid leukemia.Humans + animalsIn vitro and in vivo (primary and secondary transplant) experiments
In human and mouse AML cells and transplant mouse models, PNC-27 killed leukemic blasts and leukemia stem cells while sparing normal hematopoietic stem cell activity.
Study details
- Studied
- Human and mouse AML blasts and leukemia stem cells; human and murine AML transplant models; wild-type mice
- Main outcome
- Killing of AML bulk blasts and leukemia stem cells; effect on normal HSC activity
- Authors' conclusion
- Membrane HDM2 is a novel target; PNC-27 selectively killed AML cells including leukemia stem cells in these models, with minimal off-target hematopoietic toxicity.
- Limitations
- Preclinical (cells and mouse models); sample sizes not given in abstract.
-
Synergy between Paclitaxel and Anti-Cancer Peptide PNC-27 in the Treatment of Ovarian Cancer.Humans + animalsIn vitro cytotoxicity with isobologram analysis, plus in vivo combination with weekly paclitaxel
In ovarian cancer cells and an intraperitoneal mouse model, PNC-27 acted synergistically with paclitaxel and adding it significantly reduced tumor growth.
Key resultIsobologram showed synergy between PNC-27 and paclitaxel (combination index <1)
Study details
- Studied
- ID8 ovarian cancer cells and an intraperitoneal ID8 mouse model
- Compared with
- Paclitaxel alone
- Main outcome
- Cell viability, synergy (combination index), tumor growth
- Authors' conclusion
- PNC-27 acts synergistically with paclitaxel, could target cells surviving paclitaxel, and added to weekly paclitaxel significantly reduced tumor growth in mice.
- Limitations
- Mouse ovarian cancer cell line model; sample sizes not given in abstract.
-
Molecular Targeting of H/MDM-2 Oncoprotein in Human Colon Cancer Cells and Stem-like Colonic Epithelial-derived Progenitor Cells.Humans + animalsCell assays (flow cytometry, MTT, LDH, annexin V, caspase 3) and bioluminescence imaging of tumor growth
PNC-27 killed six colon cancer cell lines (including CD44+ stem-like cells) but not a normal colon line, and caused necrosis of tumor nodules but not normal tissue in vivo.
Study details
- Studied
- Six human colon cancer cell lines, one normal cell line (CCD-18Co), and in vivo tumors
- Main outcome
- Cell death and tumor growth
- Authors' conclusion
- PNC-27 co-localized with membrane HDM-2 only in cancer cells, caused necrosis of tumor nodules but not normal tissue, and selectively killed colon cancer stem cells.
- Limitations
- Preclinical; animal numbers not given in abstract.
-
Ex vivo Efficacy of Anti-Cancer Drug PNC-27 in the Treatment of Patient-Derived Epithelial Ovarian Cancer.Cells / labEx vivo cell culture assays (MTT, LDH)
PNC-27 inhibited growth of and was cytotoxic to primary ovarian cancer cells freshly isolated from two patients, and to chemotherapy-resistant ovarian cancer lines.
Study details
- Studied
- Primary cultures from two patient ovarian cancers (mucinous cystadenocarcinoma, high-grade papillary serous carcinoma) and established ovarian lines
- Compared with
- Control peptide PNC-29
- Main outcome
- Growth inhibition and cytotoxicity
- Authors' conclusion
- PNC-27 inhibited growth of and was cytotoxic to freshly isolated primary ovarian cancer cells and chemotherapy-resistant lines; PNC-29 had no effect. Authors see potential as a treatment.
- Limitations
- Only two primary patient-derived cell lines; in vitro only.
-
Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes.Cells / labStructural comparison, colocalization and transfection experiments
HDM-2 was found in the membranes of several cancer cell lines but not normal lines; PNC-27 bound membrane HDM-2, and normal cells engineered to express surface HDM-2 became susceptible.
Study details
- Studied
- Cancer cell lines, untransformed cell lines and HDM-2-transfected MCF-10-2A cells
- Main outcome
- Membrane HDM-2 expression and PNC-27 susceptibility
- Authors' conclusion
- PNC-27 targets HDM-2 in the membranes of cancer cells, allowing selective membranolysis; untransformed cells became susceptible after expressing membrane HDM-2.
- Limitations
- In vitro only.
-
Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic Cells.Cells / labIn vitro assays (flow cytometry, MTT, LDH release, annexin V, caspase-3)
In acute myeloid leukemia cell lines expressing membrane HDM-2, PNC-27 induced necrotic cell death, while normal hematopoietic cells were not affected.
Key resultPNC-27 induced necrosis and LDH release within 4 h in cells expressing high membrane HDM-2
Study details
- Studied
- Human AML cell lines U937, OCI-AML3 and HL60
- Main outcome
- Membrane HDM-2 expression, viability and cytotoxicity
- Authors' conclusion
- Targeting membrane HDM-2 with PNC-27 showed significant anti-leukemia activity in leukemic cell lines and could be a potential strategy to treat leukemia.
- Limitations
- In vitro cell lines only.
-
Poptosis or Peptide-Induced Transmembrane Pore Formation: A Novel Way to Kill Cancer Cells without Affecting Normal Cells.No new dataNarrative review
Review by the developers summarizing cell and nude-mouse data on PNC-27/PNC-28 pore formation in cancer cells; proposes them as potential general anti-cancer agents, with no human data presented.
Study details
- Studied
- Narrative review of PNC-27/PNC-28 peptide-induced poptosis
- Authors' conclusion
- PNC-27 and PNC-28 bind membrane HDM-2 on cancer cells and form pores causing necrosis, with no effect on normal cells in reported studies; the authors suggest they may be effective general anticancer agents.
- Limitations
- Review of mostly preclinical work; no human trials.
-
PNC27 anticancer peptide as targeting ligand significantly improved antitumor efficacy of Doxil in HDM2-expressing cells.Humans + animalsCell and mouse tumor studies comparing PNC27-Doxil with Doxil
PNC27 was attached to liposomal doxorubicin (Doxil) as a targeting ligand; in HDM2-positive C26 colon tumor mice it improved efficacy over Doxil alone, but not in HDM2-negative B16F0 melanoma.
Study details
- Studied
- C26 colon carcinoma (HDM2 positive) and B16F0 melanoma (HDM2 negative) cells and tumor-bearing BALB/c and C57BL/6 mice
- Compared with
- Doxil without PNC27
- Main outcome
- Cellular uptake, cytotoxicity and tumor therapeutic efficacy
- Authors' conclusion
- The authors conclude PNC27 is a promising targeting ligand for Doxil against HDM2-positive cancers.
- Limitations
- PNC27 was used as a targeting ligand, not as a stand-alone drug; mouse models only.
-
Chondroitin sulfate as a molecular portal that preferentially mediates the apoptotic killing of tumor cells by penetratin-directed mitochondria-disrupting peptides.Cells / labIn vitro comparison of PNC27 with engineered peptides carrying different cell-penetrating leaders
In an independent-group cell study, PNC27 killed tumor cells at IC50 values 2-3 times lower than in normal cells, but swapping its penetratin leader for other cell-penetrating peptides removed that selectivity; chondroitin sulfate on tumor cells helped entry.
Key resultIC50 values of PNC27 in tumor cells were 2-3 times lower than in normal cells
Study details
- Studied
- Human tumor cell lines and normal cells
- Compared with
- Normal cells and peptides with other leader sequences
- Main outcome
- IC50 cytotoxicity in tumor vs normal cells; chondroitin sulfate dependence
- Authors' conclusion
- The leader peptide penetratin contributes to the preferential cytotoxicity of Antp-directed peptides, and chondroitin sulfate overexpression on tumor cells is an important molecular portal.
- Limitations
- Cell lines only; selectivity was modest (2-3 fold) and depended on the penetratin leader.
-
Novel peptides from the RAS-p21 and p53 proteins for the treatment of cancer.Cells / labIn vitro testing of computer-designed ras-p21 and p53 peptides linked to penetratin
Developer's early report: p53 peptides linked to penetratin (the PNC-27 design) induced necrosis in 13 human cancer cell lines but not in normal pancreatic acinar, breast epithelial or stem cells.
Key result100 percent tumor cell necrosis in 13 different human cancer cell lines with no effect on normal pancreatic acinar, breast epithelial cells or human stem cells
Study details
- Studied
- Human cancer cell lines and untransformed cell lines
- Compared with
- Untransformed normal cells
- Main outcome
- Cancer cell necrosis and effect on normal cells
- Authors' conclusion
- The authors present these peptides as candidate cancer therapeutics selective for cancer cells.
- Limitations
- Cell lines only; from the group that designed the peptides.
Reported side effects
No human safety or efficacy data in the published literature; selectivity for cancer over normal cells is shown only in cell and mouse studies.
✓ positive · ✗ negative · ~ mixed · ? inconclusive, judged on each paper's own main outcome. Grades: A strong human evidence → D little or none. Papers and verdicts are drawn from PubMed, Europe PMC and Russian journals (CyberLeninka); not medical advice.
Discussions elsewhere
Experiences and questions about PNC-27 on other sites. Treat anecdotes with care.
PNC-27: questions people ask
What is PNC-27?
Anti-cancer research peptide. A fragment of the p53 tumor-suppressor protein joined to a cell-penetrating sequence; in lab studies it punches holes in cancer-cell membranes.
How much does PNC-27 cost?
The cheapest PNC-27 from an independently tested vendor is $0.900 per mg (Uther, PNC-27 30mg (10 Vials / Kit), $270.00). Across 27 listings from 21 vendors the median is $8.75 per mg.
Where can I buy PNC-27?
21 vendors tested by Finnrick sell PNC-27. The cheapest per mg right now: Uther ($0.900), Hangzhou Youngpeptide Biotechnology HYB ($1.05), Huatai Peptide ($1.74). 2 of them publish a lab report (COA) for PNC-27; compare lab scores and reports in the table above before buying.
How much bacteriostatic water for 5 mg of PNC-27?
Adding 2 mL of bacteriostatic water to a 5 mg vial of PNC-27 gives 2.5 mg/mL: each 10 units on a U-100 insulin syringe holds 250 mcg. With 1 mL it's 5 mg/mL (500 mcg per 10 units); with 3 mL, 1.667 mg/mL (166.7 mcg per 10 units). More water makes small amounts easier to measure. Mixing charts: 5 mg, 10 mg, 20 mg, 30 mg.
Is PNC-27 FDA approved?
Not approved. Lab research only.
Can PNC-27 be compounded in the US?
Not an FDA-approved drug and not nominated for FDA's 503A bulks list, so US pharmacies can't legally compound it. Compounding status for every peptide.
Does PNC-27 work? What does the research say?
Evidence grade C (mostly animal studies), from 10 papers: No human trials; evidence is cancer cell-line work plus a few mouse tumor studies, mostly from the developer's group. PNC-27 (a p53-derived HDM-2-binding peptide fused to a penetratin sequence) has been studied only in cancer cell lines and a few mouse tumor models; there are no published human trials. Most of the work comes from a single research group. See the papers.
What dose of PNC-27 was used in studies?
PNC-27 is tested only in animals or cells. Studied only in cancer cell lines (micromolar concentrations) and a few mouse tumor models; the abstracts do not report mg/kg doses. These are amounts used in published studies or official labels, not a recommendation.