PTD-DBM
Blocks the protein CXXC5 from shutting off Wnt signaling, which drives hair-follicle regrowth and wound healing in mouse studies.
Not approved. Research use only.
Look it up on Wikipedia3 listings across 2 independently tested vendors, ranked by price per milligram after coupon codes anyone can use. Vendors you can only order from by message are hidden.
Not an FDA-approved drug and not nominated for FDA's 503A bulks list, so US pharmacies can't legally compound it.
Daily price tracking started October 7, 2026; a price-history chart appears here once a few days have been collected.
| Vendor | Trust | Listing | Vials | Price | Per mg | |
|---|---|---|---|---|---|---|
Qingdao Sigma Chemical QSC #69 by metascore |
PTD-DBM 5mg | 20-Vial Kit | Wnt/CXXC5 Pathway Modulator | 20 × 5 mg = 100 mg | $590.00 $29.50 per vial |
$5.90 | Buy | |
Qingdao Sigma Chemical QSC #69 by metascore |
PTD-DBM 5mg | 10-Vial Kit | Wnt/CXXC5 Pathway Modulator | 10 × 5 mg = 50 mg | $320.00 $32.00 per vial |
$6.40 | Buy | |
Core Peptides #282 by metascore |
Metascore 70 medium confidenceFinnrick 76%PepIndex 24/100Bought vials 92% of label · 4 testsTitrateLab · PeptideBase · Peptide Critic · PeptideCheckedNo report for thisOnline checkout |
PTD-DBM – 5MG | 1 × 5 mg | $89.00 | $17.80 | Buy |
Mixing a 5 mg vial
What each common amount of bacteriostatic water gives you on a U-100 insulin syringe. Pick a vial size above to change it.
| Water | Strength | Per 10 units (0.1 mL) | Per unit |
|---|---|---|---|
| 1 mL | 5 mg/mL | 500 mcg | 50 mcg |
| 2 mL | 2.5 mg/mL | 250 mcg | 25 mcg |
| 3 mL | 1.667 mg/mL | 166.7 mcg | 16.67 mcg |
| 5 mL | 1 mg/mL | 100 mcg | 10 mcg |
Doses studied in research Animal or lab studies only
What was given to people (or animals) in published studies and official labels, each linked to its source. This is not a recommendation: study products, purity and supervision differ from research-grade vials.
Animal studies: Applied topically or in a hydrogel patch to mouse skin and tested in cell cultures; the abstracts in our pool do not state doses.
No human trials found; all published work is from one research group. Doses in animal studies do not translate directly to people.
What the research says
PTD-DBM is an experimental peptide that blocks the CXXC5-Dishevelled interaction to switch on Wnt/beta-catenin signaling; all published work comes from one Korean research group and consists of mouse and cell studies on hair regrowth and wound healing. No human trials were found in PubMed.
Key papers ✓ 5? 1
-
Revolutionary Approaches to Hair Regrowth: Follicle Neogenesis, Wnt/ß-Catenin Signaling, and Emerging Therapies.No new dataNarrative review
Narrative review of emerging hair-loss therapies discusses PTD-DBM as a Wnt-pathway activator but states such therapies still need research to validate efficacy and risk profile.
Study details
- Studied
- Alopecia therapies, including the CXXC5-targeting peptide PTD-DBM
- Main outcome
- Hair follicle neogenesis and Wnt/beta-catenin-modulating therapies
- Authors' conclusion
- Peptides such as PTD-DBM, which activate Wnt/beta-catenin by interfering with CXXC5, show potential, but these novel therapies require further research to validate efficacy and risk profile.
- Limitations
- Narrative review with no original data; clinical efficacy claims not quantified in the abstract.
-
Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis.Humans + animalsHuman tissue, in vitro and mouse studies incl. a competitor peptide disrupting CXXC5-Dishevelled
CXXC5 was elevated in balding human scalp; in mice, a competitor peptide blocking CXXC5-Dishevelled binding activated Wnt signaling and accelerated hair regrowth and wound-induced hair follicle formation.
Study details
- Studied
- Human balding scalp tissue, human dermal papilla cells, CXXC5-/- mice and wild-type mice
- Main outcome
- Hair regrowth and wound-induced hair follicle neogenesis
- Authors' conclusion
- CXXC5 is a negative regulator of Wnt/beta-catenin; disrupting its interaction with Dishevelled with a competitor peptide accelerated hair regrowth and wound-induced hair follicle neogenesis in mice, suggesting a target for hair loss.
- Limitations
- Preclinical; numbers not in the abstract.
-
CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2.Animalssize not reportedMouse study with PTD-DBM treatment or Cxxc5 knockout, incl. wound-induced hair neogenesis model
In mice, PTD-DBM (or CXXC5 knockout) reversed hair loss induced by prostaglandin D2 and countered DHT-linked hair-loss signaling.
Study details
- Studied
- Mice with prostaglandin D2- or DHT-induced hair loss, including Cxxc5 knockout mice
- Main outcome
- Hair loss and neogenic hair growth
- Authors' conclusion
- PGD2-induced hair loss was restored by PTD-DBM or Cxxc5 knockout, and DHT-induced hair loss was alleviated by inhibiting both GSK-3beta and CXXC5; CXXC5 mediates hair loss via the DHT-PGD2 axis.
- Limitations
- Mouse study; numbers not in the abstract.
-
The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing.Humans + animalsHuman tissue, in vitro and mouse studies; PTD-DBM with valproic acid co-treatment
PTD-DBM activated beta-catenin and collagen production in cells, and combined with valproic acid accelerated skin wound healing in mice.
Study details
- Studied
- Human wound tissue, cultured cells, CXXC5-/- mice and wild-type mice with skin wounds
- Main outcome
- Cutaneous wound healing; beta-catenin and collagen production
- Authors' conclusion
- CXXC5 negatively regulates wound healing via Dishevelled; PTD-DBM activated beta-catenin and collagen in vitro, and with valproic acid synergistically accelerated wound healing in mice.
- Limitations
- Preclinical; effect of PTD-DBM alone in vivo not stated in the abstract.
-
Adhesive Hydrogel Patch-Mediated Combination Drug Therapy Induces Regenerative Wound Healing through Reconstruction of Regenerative Microenvironment.Animalssize not reportedMouse wound-healing study with patches loaded with PTD-DBM and/or valproic acid
An adhesive hydrogel patch loaded with PTD-DBM and/or valproic acid reduced scar formation and promoted regenerative wound healing in mice.
Study details
- Studied
- Mice with wounds treated with pyrogallol-functionalized hyaluronic acid (HA-PG) patches
- Main outcome
- Scar formation and regenerative wound healing markers
- Authors' conclusion
- Patches loaded with PTD-DBM and/or valproic acid significantly inhibited scar formation and induced stem cell markers and collagen III, suggesting potential to promote wound healing and scar attenuation.
- Limitations
- Mouse study; patch material contributes to the effect; numbers not in the abstract.
-
CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation.Humans + animalsMouse genetics, in vitro osteoblast differentiation and ex vivo skull culture with a competitor peptide
Blocking the CXXC5-Dishevelled interaction with a competitor peptide activated Wnt signaling and osteoblast differentiation and thickened cultured mouse skull bone.
Study details
- Studied
- Cxxc5-deficient mice, osteoblast cultures and ex vivo cultured mouse calvariae
- Main outcome
- Bone mineral density, osteoblast differentiation, calvarial thickness
- Authors' conclusion
- CXXC5 deficiency raised bone mineral density in mice; blocking the Dvl-CXXC5 interaction with a competitor peptide activated Wnt signaling and osteoblast differentiation and thickened cultured calvariae.
- Limitations
- Peptide tested in cells and ex vivo bone only; numbers not in the abstract.
Reported side effects
No human safety data in the published literature; Wnt-pathway activation has theoretical long-term risks that have not been studied for this peptide.
✓ positive · ✗ negative · ~ mixed · ? inconclusive, judged on each paper's own main outcome. Grades: A strong human evidence → D little or none. Papers and verdicts are drawn from PubMed, Europe PMC and Russian journals (CyberLeninka); not medical advice.
Discussions elsewhere
Experiences and questions about PTD-DBM on other sites. Treat anecdotes with care.
PTD-DBM: questions people ask
What is PTD-DBM?
Wnt-pathway activating peptide. Blocks the protein CXXC5 from shutting off Wnt signaling, which drives hair-follicle regrowth and wound healing in mouse studies.
How much does PTD-DBM cost?
The cheapest PTD-DBM from an independently tested vendor is $5.90 per mg (Qingdao Sigma Chemical QSC, PTD-DBM 5mg | 20-Vial Kit | Wnt/CXXC5 Pathway Modulator, $590.00). Across 3 listings from 2 vendors the median is $6.40 per mg.
Where can I buy PTD-DBM?
2 vendors tested by Finnrick sell PTD-DBM. The cheapest per mg right now: Qingdao Sigma Chemical QSC ($5.90), Core Peptides ($17.80). 0 of them publish a lab report (COA) for PTD-DBM; compare lab scores and reports in the table above before buying.
How much bacteriostatic water for 5 mg of PTD-DBM?
Adding 2 mL of bacteriostatic water to a 5 mg vial of PTD-DBM gives 2.5 mg/mL: each 10 units on a U-100 insulin syringe holds 250 mcg. With 1 mL it's 5 mg/mL (500 mcg per 10 units); with 3 mL, 1.667 mg/mL (166.7 mcg per 10 units). More water makes small amounts easier to measure. Mixing charts: 5 mg.
Is PTD-DBM FDA approved?
Not approved. Research use only.
Can PTD-DBM be compounded in the US?
Not an FDA-approved drug and not nominated for FDA's 503A bulks list, so US pharmacies can't legally compound it. Compounding status for every peptide.
Does PTD-DBM work? What does the research say?
Evidence grade C (mostly animal studies), from 6 papers: Several mouse studies from one Korean group show hair regrowth and better wound healing; no human trials. PTD-DBM is an experimental peptide that blocks the CXXC5-Dishevelled interaction to switch on Wnt/beta-catenin signaling; all published work comes from one Korean research group and consists of mouse and cell studies on hair regrowth and wound healing. No human trials were found in PubMed. See the papers.
What dose of PTD-DBM was used in studies?
PTD-DBM is tested only in animals or cells. Applied topically or in a hydrogel patch to mouse skin and tested in cell cultures; the abstracts in our pool do not state doses. These are amounts used in published studies or official labels, not a recommendation.