Cagrilintide vs Semaglutide
Cagrilintide: Long-acting amylin analog. Semaglutide: GLP-1 receptor agonist. Per milligram, Semaglutide is cheaper right now (USD 1.25 vs USD 0.238 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Cagrilintide
Mimics amylin, a hormone released with insulin that promotes fullness and slows stomach emptying. Usually studied together with semaglutide ("CagriSema").
- What it is
- Long-acting amylin analog
- Category
- GLP-1 & metabolic
- Status
- Investigational (Novo Nordisk, Phase 3 as CagriSema). Not approved.
- Cheapest
- USD 1.25 per mg (Nantong Guangyuan Chemical GYC)
- Median price
- USD 5.60 per mg
- Vendors
- 70 independently tested, 18 with a lab report
- Research
- Grade A: Strong human evidence (7 papers)
- Studied as
- studied in people
- Reported side effects
- Gastrointestinal events (nausea, vomiting, diarrhea, constipation, abdominal pain), mostly transient and mild-moderate; Vomiting (higher with the combination than semaglutide alone); Injection/administration-site reactions; Discontinuation due to adverse events
Semaglutide
A long-acting analog of the gut hormone GLP-1 that increases insulin release after meals, slows stomach emptying and reduces appetite. Large trials showed substantial weight loss and cardiovascular benefit.
- What it is
- GLP-1 receptor agonist
- Category
- GLP-1 & metabolic
- Status
- FDA-approved as Ozempic and Rybelsus (type 2 diabetes) and Wegovy (weight management).
- Cheapest
- USD 0.238 per mg (Peptides Book)
- Median price
- USD 3.00 per mg
- Vendors
- 64 independently tested, 22 with a lab report
- Research
- Grade A: Strong human evidence (8 papers)
- Studied as
- an approved drug
- Reported side effects
- Nausea, diarrhea and other gastrointestinal events (mostly mild-moderate, transient); Discontinuation due to adverse events; Serious hepatobiliary/GI events such as acute pancreatitis and gallstones; Nonarteritic anterior ischemic optic neuropathy (observational association)
Cheapest tested vendors for Cagrilintide and Semaglutide
Lowest price per milligram at up to three independently tested vendors each. Rankings are by price only; open a vendor to see its lab results.
| Peptide | Vendor | Per mg |
|---|---|---|
| Cagrilintide | Nantong Guangyuan Chemical GYC | USD 1.25 |
| BeiBangAn | USD 1.35 | |
| LN Peptides | USD 1.35 | |
| Semaglutide | Peptides Book | USD 0.238 |
| BFF Chem | USD 0.350 | |
| Bfflink | USD 0.350 |
Questions people ask
What is the difference between Cagrilintide and Semaglutide?
Cagrilintide: Long-acting amylin analog. Semaglutide: GLP-1 receptor agonist. Per milligram, Semaglutide is cheaper right now (USD 1.25 vs USD 0.238 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Which is cheaper, Cagrilintide or Semaglutide?
Semaglutide is cheaper per mg: USD 1.25 for Cagrilintide vs USD 0.238 for Semaglutide at the cheapest independently tested vendor. The median listing is USD 5.60 per mg for Cagrilintide and USD 3.00 per mg for Semaglutide.
Which is easier to find from a tested vendor, Cagrilintide or Semaglutide?
Cagrilintide is sold by more independently tested vendors: 70 list Cagrilintide (18 publish a lab report for it) and 64 list Semaglutide (22 with a lab report).
Which has more published research, Cagrilintide or Semaglutide?
Cagrilintide is graded A (strong human evidence) from 7 papers and Semaglutide is graded A (strong human evidence) from 8 papers. Grades count studies of the exact compound only; they describe how much evidence exists, not which one is better.
Are Cagrilintide and Semaglutide FDA approved?
Cagrilintide: Investigational (Novo Nordisk, Phase 3 as CagriSema). Not approved. Semaglutide: FDA-approved as Ozempic and Rybelsus (type 2 diabetes) and Wegovy (weight management).