Retatrutide vs Semaglutide
Retatrutide: Triple GIP / GLP-1 / glucagon receptor agonist. Semaglutide: GLP-1 receptor agonist. Per milligram, Semaglutide is cheaper right now (USD 0.425 vs USD 0.238 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Retatrutide
Adds glucagon-receptor activity, which raises energy expenditure, on top of the two incretin receptors. Phase 2 trials reported the largest average weight loss of any drug in its class so far.
- What it is
- Triple GIP / GLP-1 / glucagon receptor agonist
- Category
- GLP-1 & metabolic
- Status
- Investigational (Eli Lilly, Phase 3 trials). Not approved anywhere.
- Cheapest
- USD 0.425 per mg (BeiBangAn)
- Median price
- USD 3.15 per mg
- Vendors
- 89 independently tested, 50 with a lab report
- Research
- Grade A: Strong human evidence (7 papers)
- Studied as
- studied in people
- Reported side effects
- Nausea, diarrhea, vomiting, constipation (dose-related, mostly mild-moderate); Increased heart rate; Hypersensitivity reactions (non-severe); Discontinuation due to adverse events
Semaglutide
A long-acting analog of the gut hormone GLP-1 that increases insulin release after meals, slows stomach emptying and reduces appetite. Large trials showed substantial weight loss and cardiovascular benefit.
- What it is
- GLP-1 receptor agonist
- Category
- GLP-1 & metabolic
- Status
- FDA-approved as Ozempic and Rybelsus (type 2 diabetes) and Wegovy (weight management).
- Cheapest
- USD 0.238 per mg (Peptides Book)
- Median price
- USD 3.00 per mg
- Vendors
- 64 independently tested, 22 with a lab report
- Research
- Grade A: Strong human evidence (8 papers)
- Studied as
- an approved drug
- Reported side effects
- Nausea, diarrhea and other gastrointestinal events (mostly mild-moderate, transient); Discontinuation due to adverse events; Serious hepatobiliary/GI events such as acute pancreatitis and gallstones; Nonarteritic anterior ischemic optic neuropathy (observational association)
Cheapest tested vendors for Retatrutide and Semaglutide
Lowest price per milligram at up to three independently tested vendors each. Rankings are by price only; open a vendor to see its lab results.
| Peptide | Vendor | Per mg |
|---|---|---|
| Retatrutide | BeiBangAn | USD 0.425 |
| LN Peptides | USD 0.425 | |
| Peptides Book | USD 0.430 | |
| Semaglutide | Peptides Book | USD 0.238 |
| BFF Chem | USD 0.350 | |
| Bfflink | USD 0.350 |
Questions people ask
What is the difference between Retatrutide and Semaglutide?
Retatrutide: Triple GIP / GLP-1 / glucagon receptor agonist. Semaglutide: GLP-1 receptor agonist. Per milligram, Semaglutide is cheaper right now (USD 0.425 vs USD 0.238 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Which is cheaper, Retatrutide or Semaglutide?
Semaglutide is cheaper per mg: USD 0.425 for Retatrutide vs USD 0.238 for Semaglutide at the cheapest independently tested vendor. The median listing is USD 3.15 per mg for Retatrutide and USD 3.00 per mg for Semaglutide.
Which is easier to find from a tested vendor, Retatrutide or Semaglutide?
Retatrutide is sold by more independently tested vendors: 89 list Retatrutide (50 publish a lab report for it) and 64 list Semaglutide (22 with a lab report).
Which has more published research, Retatrutide or Semaglutide?
Retatrutide is graded A (strong human evidence) from 7 papers and Semaglutide is graded A (strong human evidence) from 8 papers. Grades count studies of the exact compound only; they describe how much evidence exists, not which one is better.
Are Retatrutide and Semaglutide FDA approved?
Retatrutide: Investigational (Eli Lilly, Phase 3 trials). Not approved anywhere. Semaglutide: FDA-approved as Ozempic and Rybelsus (type 2 diabetes) and Wegovy (weight management).