Retatrutide vs Survodutide
Retatrutide: Triple GIP / GLP-1 / glucagon receptor agonist. Survodutide: Dual GLP-1 / glucagon receptor agonist. Per milligram, Retatrutide is cheaper right now ($0.350 vs $1.70 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Retatrutide
Adds glucagon-receptor activity, which raises energy expenditure, on top of the two incretin receptors. Phase 2 trials reported the largest average weight loss of any drug in its class so far.
- What it is
- Triple GIP / GLP-1 / glucagon receptor agonist
- Category
- GLP-1 & metabolic
- Status
- Investigational (Eli Lilly, Phase 3 trials). Not approved anywhere.
- Cheapest
- $0.350 per mg (Shanghai Wibson Biotechnology WBS)
- Median price
- $2.92 per mg
- Vendors
- 98 independently tested, 53 with a lab report
- Research
- Grade A: Strong human evidence (7 papers)
- Studied as
- studied in people
- Reported side effects
- Nausea, diarrhea, vomiting, constipation (dose-related, mostly mild-moderate); Increased heart rate; Hypersensitivity reactions (non-severe); Discontinuation due to adverse events
Survodutide
Studied for weight loss and for fatty liver disease (MASH), where glucagon activity may help reduce liver fat.
- What it is
- Dual GLP-1 / glucagon receptor agonist
- Category
- GLP-1 & metabolic
- Status
- Investigational (Boehringer Ingelheim, Phase 3). Not approved.
- Cheapest
- $1.70 per mg (Andy Peps Studio)
- Median price
- $4.50 per mg
- Vendors
- 32 independently tested, 4 with a lab report
- Research
- Grade A: Strong human evidence (10 papers)
- Studied as
- studied in people
- Reported side effects
- Gastrointestinal events (nausea, diarrhea, vomiting), dose-related; Drug-related adverse events in people with cirrhosis; Serious adverse events (similar to placebo)
Questions people ask
What is the difference between Retatrutide and Survodutide?
Retatrutide: Triple GIP / GLP-1 / glucagon receptor agonist. Survodutide: Dual GLP-1 / glucagon receptor agonist. Per milligram, Retatrutide is cheaper right now ($0.350 vs $1.70 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Which is cheaper, Retatrutide or Survodutide?
Retatrutide is cheaper per mg: $0.350 for Retatrutide vs $1.70 for Survodutide at the cheapest independently tested vendor.