Mazdutide vs Retatrutide
Mazdutide: Dual GLP-1 / glucagon receptor agonist. Retatrutide: Triple GIP / GLP-1 / glucagon receptor agonist. Per milligram, Retatrutide is cheaper right now ($1.80 vs $0.350 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Mazdutide
Combines appetite reduction from GLP-1 with the energy-expenditure effect of glucagon-receptor activation; studied for obesity and type 2 diabetes.
- What it is
- Dual GLP-1 / glucagon receptor agonist
- Category
- GLP-1 & metabolic
- Status
- Approved in China in 2025 (Innovent). Not approved in the US.
- Cheapest
- $1.80 per mg (Andy Peps Studio)
- Median price
- $3.50 per mg
- Vendors
- 22 independently tested, 3 with a lab report
- Research
- Grade A: Strong human evidence (7 papers)
- Studied as
- studied in people
- Reported side effects
- Diarrhea; Nausea and vomiting; Decreased appetite; Hypoglycemia (in type 2 diabetes; similar to placebo)
Retatrutide
Adds glucagon-receptor activity, which raises energy expenditure, on top of the two incretin receptors. Phase 2 trials reported the largest average weight loss of any drug in its class so far.
- What it is
- Triple GIP / GLP-1 / glucagon receptor agonist
- Category
- GLP-1 & metabolic
- Status
- Investigational (Eli Lilly, Phase 3 trials). Not approved anywhere.
- Cheapest
- $0.350 per mg (Shanghai Wibson Biotechnology WBS)
- Median price
- $2.92 per mg
- Vendors
- 98 independently tested, 53 with a lab report
- Research
- Grade A: Strong human evidence (7 papers)
- Studied as
- studied in people
- Reported side effects
- Nausea, diarrhea, vomiting, constipation (dose-related, mostly mild-moderate); Increased heart rate; Hypersensitivity reactions (non-severe); Discontinuation due to adverse events
Questions people ask
What is the difference between Mazdutide and Retatrutide?
Mazdutide: Dual GLP-1 / glucagon receptor agonist. Retatrutide: Triple GIP / GLP-1 / glucagon receptor agonist. Per milligram, Retatrutide is cheaper right now ($1.80 vs $0.350 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Which is cheaper, Mazdutide or Retatrutide?
Retatrutide is cheaper per mg: $1.80 for Mazdutide vs $0.350 for Retatrutide at the cheapest independently tested vendor.