Mazdutide vs Tirzepatide
Mazdutide: Dual GLP-1 / glucagon receptor agonist. Tirzepatide: Dual GIP / GLP-1 receptor agonist. Per milligram, Tirzepatide is cheaper right now ($1.80 vs $0.230 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Mazdutide
Combines appetite reduction from GLP-1 with the energy-expenditure effect of glucagon-receptor activation; studied for obesity and type 2 diabetes.
- What it is
- Dual GLP-1 / glucagon receptor agonist
- Category
- GLP-1 & metabolic
- Status
- Approved in China in 2025 (Innovent). Not approved in the US.
- Cheapest
- $1.80 per mg (Andy Peps Studio)
- Median price
- $3.50 per mg
- Vendors
- 22 independently tested, 3 with a lab report
- Research
- Grade A: Strong human evidence (7 papers)
- Studied as
- studied in people
- Reported side effects
- Diarrhea; Nausea and vomiting; Decreased appetite; Hypoglycemia (in type 2 diabetes; similar to placebo)
Tirzepatide
Activates both the GIP and GLP-1 incretin receptors, lowering blood sugar and appetite. In trials it produced more weight loss on average than GLP-1-only drugs.
- What it is
- Dual GIP / GLP-1 receptor agonist
- Category
- GLP-1 & metabolic
- Status
- FDA-approved as Mounjaro (type 2 diabetes) and Zepbound (weight management, obstructive sleep apnea).
- Cheapest
- $0.230 per mg (Andy Peps Studio)
- Median price
- $1.68 per mg
- Vendors
- 92 independently tested, 45 with a lab report
- Research
- Grade A: Strong human evidence (8 papers)
- Studied as
- an approved drug
- Reported side effects
- Nausea, diarrhea, vomiting and other GI events (mostly mild-moderate, during dose escalation); Discontinuation due to adverse events; Serious adverse events; Hypoglycemia (in type 2 diabetes)
Questions people ask
What is the difference between Mazdutide and Tirzepatide?
Mazdutide: Dual GLP-1 / glucagon receptor agonist. Tirzepatide: Dual GIP / GLP-1 receptor agonist. Per milligram, Tirzepatide is cheaper right now ($1.80 vs $0.230 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Which is cheaper, Mazdutide or Tirzepatide?
Tirzepatide is cheaper per mg: $1.80 for Mazdutide vs $0.230 for Tirzepatide at the cheapest independently tested vendor.