Cagrilintide vs Tirzepatide
Cagrilintide: Long-acting amylin analog. Tirzepatide: Dual GIP / GLP-1 receptor agonist. Per milligram, Tirzepatide is cheaper right now (USD 1.25 vs USD 0.230 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Cagrilintide
Mimics amylin, a hormone released with insulin that promotes fullness and slows stomach emptying. Usually studied together with semaglutide ("CagriSema").
- What it is
- Long-acting amylin analog
- Category
- GLP-1 & metabolic
- Status
- Investigational (Novo Nordisk, Phase 3 as CagriSema). Not approved.
- Cheapest
- USD 1.25 per mg (Nantong Guangyuan Chemical GYC)
- Median price
- USD 5.60 per mg
- Vendors
- 70 independently tested, 18 with a lab report
- Research
- Grade A: Strong human evidence (7 papers)
- Studied as
- studied in people
- Reported side effects
- Gastrointestinal events (nausea, vomiting, diarrhea, constipation, abdominal pain), mostly transient and mild-moderate; Vomiting (higher with the combination than semaglutide alone); Injection/administration-site reactions; Discontinuation due to adverse events
Tirzepatide
Activates both the GIP and GLP-1 incretin receptors, lowering blood sugar and appetite. In trials it produced more weight loss on average than GLP-1-only drugs.
- What it is
- Dual GIP / GLP-1 receptor agonist
- Category
- GLP-1 & metabolic
- Status
- FDA-approved as Mounjaro (type 2 diabetes) and Zepbound (weight management, obstructive sleep apnea).
- Cheapest
- USD 0.230 per mg (BeiBangAn)
- Median price
- USD 2.00 per mg
- Vendors
- 81 independently tested, 43 with a lab report
- Research
- Grade A: Strong human evidence (8 papers)
- Studied as
- an approved drug
- Reported side effects
- Nausea, diarrhea, vomiting and other GI events (mostly mild-moderate, during dose escalation); Discontinuation due to adverse events; Serious adverse events; Hypoglycemia (in type 2 diabetes)
Cheapest tested vendors for Cagrilintide and Tirzepatide
Lowest price per milligram at up to three independently tested vendors each. Rankings are by price only; open a vendor to see its lab results.
| Peptide | Vendor | Per mg |
|---|---|---|
| Cagrilintide | Nantong Guangyuan Chemical GYC | USD 1.25 |
| BeiBangAn | USD 1.35 | |
| LN Peptides | USD 1.35 | |
| Tirzepatide | BeiBangAn | USD 0.230 |
| LN Peptides | USD 0.230 | |
| Mix Peptides | USD 0.275 |
Questions people ask
What is the difference between Cagrilintide and Tirzepatide?
Cagrilintide: Long-acting amylin analog. Tirzepatide: Dual GIP / GLP-1 receptor agonist. Per milligram, Tirzepatide is cheaper right now (USD 1.25 vs USD 0.230 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Which is cheaper, Cagrilintide or Tirzepatide?
Tirzepatide is cheaper per mg: USD 1.25 for Cagrilintide vs USD 0.230 for Tirzepatide at the cheapest independently tested vendor. The median listing is USD 5.60 per mg for Cagrilintide and USD 2.00 per mg for Tirzepatide.
Which is easier to find from a tested vendor, Cagrilintide or Tirzepatide?
Tirzepatide is sold by more independently tested vendors: 70 list Cagrilintide (18 publish a lab report for it) and 81 list Tirzepatide (43 with a lab report).
Which has more published research, Cagrilintide or Tirzepatide?
Cagrilintide is graded A (strong human evidence) from 7 papers and Tirzepatide is graded A (strong human evidence) from 8 papers. Grades count studies of the exact compound only; they describe how much evidence exists, not which one is better.
Are Cagrilintide and Tirzepatide FDA approved?
Cagrilintide: Investigational (Novo Nordisk, Phase 3 as CagriSema). Not approved. Tirzepatide: FDA-approved as Mounjaro (type 2 diabetes) and Zepbound (weight management, obstructive sleep apnea).