Orforglipron vs Tirzepatide
Orforglipron: Oral small-molecule GLP-1 receptor agonist. Tirzepatide: Dual GIP / GLP-1 receptor agonist. Per milligram, Orforglipron is cheaper right now ($0.190 vs $0.230 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Orforglipron
A non-peptide pill that activates the GLP-1 receptor and can be taken without food or water restrictions. Phase 3 ATTAIN trials showed dose-dependent weight loss (about 7-11% at 72 weeks).
- What it is
- Oral small-molecule GLP-1 receptor agonist
- Category
- GLP-1 & metabolic
- Status
- FDA-approved April 2026 as Foundayo (Eli Lilly) for chronic weight management.
- Cheapest
- $0.190 per mg (Peptide Group Buy PGB)
- Median price
- $0.190 per mg
- Vendors
- 1 independently tested, 0 with a lab report
- Research
- Not reviewed
Tirzepatide
Activates both the GIP and GLP-1 incretin receptors, lowering blood sugar and appetite. In trials it produced more weight loss on average than GLP-1-only drugs.
- What it is
- Dual GIP / GLP-1 receptor agonist
- Category
- GLP-1 & metabolic
- Status
- FDA-approved as Mounjaro (type 2 diabetes) and Zepbound (weight management, obstructive sleep apnea).
- Cheapest
- $0.230 per mg (Andy Peps Studio)
- Median price
- $1.68 per mg
- Vendors
- 92 independently tested, 45 with a lab report
- Research
- Grade A: Strong human evidence (8 papers)
- Studied as
- an approved drug
- Reported side effects
- Nausea, diarrhea, vomiting and other GI events (mostly mild-moderate, during dose escalation); Discontinuation due to adverse events; Serious adverse events; Hypoglycemia (in type 2 diabetes)
Questions people ask
What is the difference between Orforglipron and Tirzepatide?
Orforglipron: Oral small-molecule GLP-1 receptor agonist. Tirzepatide: Dual GIP / GLP-1 receptor agonist. Per milligram, Orforglipron is cheaper right now ($0.190 vs $0.230 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Which is cheaper, Orforglipron or Tirzepatide?
Orforglipron is cheaper per mg: $0.190 for Orforglipron vs $0.230 for Tirzepatide at the cheapest independently tested vendor.