Cagrilintide vs Retatrutide
Cagrilintide: Long-acting amylin analog. Retatrutide: Triple GIP / GLP-1 / glucagon receptor agonist. Per milligram, Retatrutide is cheaper right now ($1.25 vs $0.350 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Cagrilintide
Mimics amylin, a hormone released with insulin that promotes fullness and slows stomach emptying. Usually studied together with semaglutide ("CagriSema").
- What it is
- Long-acting amylin analog
- Category
- GLP-1 & metabolic
- Status
- Investigational (Novo Nordisk, Phase 3 as CagriSema). Not approved.
- Cheapest
- $1.25 per mg (Nantong Guangyuan Chemical GYC)
- Median price
- $5.00 per mg
- Vendors
- 79 independently tested, 21 with a lab report
- Research
- Grade A: Strong human evidence (7 papers)
- Studied as
- studied in people
- Reported side effects
- Gastrointestinal events (nausea, vomiting, diarrhea, constipation, abdominal pain), mostly transient and mild-moderate; Vomiting (higher with the combination than semaglutide alone); Injection/administration-site reactions; Discontinuation due to adverse events
Retatrutide
Adds glucagon-receptor activity, which raises energy expenditure, on top of the two incretin receptors. Phase 2 trials reported the largest average weight loss of any drug in its class so far.
- What it is
- Triple GIP / GLP-1 / glucagon receptor agonist
- Category
- GLP-1 & metabolic
- Status
- Investigational (Eli Lilly, Phase 3 trials). Not approved anywhere.
- Cheapest
- $0.350 per mg (Shanghai Wibson Biotechnology WBS)
- Median price
- $2.92 per mg
- Vendors
- 98 independently tested, 53 with a lab report
- Research
- Grade A: Strong human evidence (7 papers)
- Studied as
- studied in people
- Reported side effects
- Nausea, diarrhea, vomiting, constipation (dose-related, mostly mild-moderate); Increased heart rate; Hypersensitivity reactions (non-severe); Discontinuation due to adverse events
Questions people ask
What is the difference between Cagrilintide and Retatrutide?
Cagrilintide: Long-acting amylin analog. Retatrutide: Triple GIP / GLP-1 / glucagon receptor agonist. Per milligram, Retatrutide is cheaper right now ($1.25 vs $0.350 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Which is cheaper, Cagrilintide or Retatrutide?
Retatrutide is cheaper per mg: $1.25 for Cagrilintide vs $0.350 for Retatrutide at the cheapest independently tested vendor.