Mazdutide vs Semaglutide
Mazdutide: Dual GLP-1 / glucagon receptor agonist. Semaglutide: GLP-1 receptor agonist. Per milligram, Semaglutide is cheaper right now (USD 1.80 vs USD 0.238 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Mazdutide
Combines appetite reduction from GLP-1 with the energy-expenditure effect of glucagon-receptor activation; studied for obesity and type 2 diabetes.
- What it is
- Dual GLP-1 / glucagon receptor agonist
- Category
- GLP-1 & metabolic
- Status
- Approved in China in 2025 (Innovent). Not approved in the US.
- Cheapest
- USD 1.80 per mg (BeiBangAn)
- Median price
- USD 3.52 per mg
- Vendors
- 20 independently tested, 1 with a lab report
- Research
- Grade A: Strong human evidence (7 papers)
- Studied as
- studied in people
- Reported side effects
- Diarrhea; Nausea and vomiting; Decreased appetite; Hypoglycemia (in type 2 diabetes; similar to placebo)
Semaglutide
A long-acting analog of the gut hormone GLP-1 that increases insulin release after meals, slows stomach emptying and reduces appetite. Large trials showed substantial weight loss and cardiovascular benefit.
- What it is
- GLP-1 receptor agonist
- Category
- GLP-1 & metabolic
- Status
- FDA-approved as Ozempic and Rybelsus (type 2 diabetes) and Wegovy (weight management).
- Cheapest
- USD 0.238 per mg (Peptides Book)
- Median price
- USD 3.00 per mg
- Vendors
- 64 independently tested, 22 with a lab report
- Research
- Grade A: Strong human evidence (8 papers)
- Studied as
- an approved drug
- Reported side effects
- Nausea, diarrhea and other gastrointestinal events (mostly mild-moderate, transient); Discontinuation due to adverse events; Serious hepatobiliary/GI events such as acute pancreatitis and gallstones; Nonarteritic anterior ischemic optic neuropathy (observational association)
Cheapest tested vendors for Mazdutide and Semaglutide
Lowest price per milligram at up to three independently tested vendors each. Rankings are by price only; open a vendor to see its lab results.
| Peptide | Vendor | Per mg |
|---|---|---|
| Mazdutide | BeiBangAn | USD 1.80 |
| Huaian Dinglin Trading | USD 1.80 | |
| LN Peptides | USD 1.80 | |
| Semaglutide | Peptides Book | USD 0.238 |
| BFF Chem | USD 0.350 | |
| Bfflink | USD 0.350 |
Questions people ask
What is the difference between Mazdutide and Semaglutide?
Mazdutide: Dual GLP-1 / glucagon receptor agonist. Semaglutide: GLP-1 receptor agonist. Per milligram, Semaglutide is cheaper right now (USD 1.80 vs USD 0.238 at the cheapest tested vendor). Prices per mg compare cost, not effect: the amounts used in studies differ between compounds.
Which is cheaper, Mazdutide or Semaglutide?
Semaglutide is cheaper per mg: USD 1.80 for Mazdutide vs USD 0.238 for Semaglutide at the cheapest independently tested vendor. The median listing is USD 3.52 per mg for Mazdutide and USD 3.00 per mg for Semaglutide.
Which is easier to find from a tested vendor, Mazdutide or Semaglutide?
Semaglutide is sold by more independently tested vendors: 20 list Mazdutide (1 publish a lab report for it) and 64 list Semaglutide (22 with a lab report).
Which has more published research, Mazdutide or Semaglutide?
Mazdutide is graded A (strong human evidence) from 7 papers and Semaglutide is graded A (strong human evidence) from 8 papers. Grades count studies of the exact compound only; they describe how much evidence exists, not which one is better.
Are Mazdutide and Semaglutide FDA approved?
Mazdutide: Approved in China in 2025 (Innovent). Not approved in the US. Semaglutide: FDA-approved as Ozempic and Rybelsus (type 2 diabetes) and Wegovy (weight management).