PE-22-28
A shortened version of the peptide spadin that blocks the TREK-1 potassium channel; showed fast antidepressant-like effects in mice.
Not approved. Research use only.
Look it up on Wikipedia34 listings across 29 independently tested vendors, ranked by price per milligram after coupon codes anyone can use. Vendors you can only order from by message are hidden.
Some links here are affiliate links: if you buy through one, this site may earn a commission at no extra cost to you. Prices, rankings and plans are worked out the same way whether or not a vendor pays one.
Not an FDA-approved drug and not nominated for FDA's 503A bulks list, so US pharmacies can't legally compound it.
Daily price tracking started October 7, 2026; a price-history chart appears here once a few days have been collected.
| Vendor | Trust | Listing | Vials | Price | Per mg | |
|---|---|---|---|---|---|---|
Andy Peps Studio #64 by metascore · China |
PE10 PE-22-28 10mg * 10 vials | 10 × 10 mg = 100 mg | $65.00 $6.50 per vial |
$0.650 | Buy | |
Baohua Dongnuo Biotechnology BHD #77 by metascore · China |
PE10 PE-22-28 10mg * 10 vials | 10 × 10 mg = 100 mg | $65.00 $6.50 per vial |
$0.650 | Buy | |
LN Peptides #254 by metascore · China |
Metascore 71Finnrick 72%Bought vials 99% of label · 39 testsTitrateLabNo report for thisOnline checkout |
PE10 PE-22-28 10mg * 10 vials | 10 × 10 mg = 100 mg | $65.00 $6.50 per vial |
$0.650 | Buy |
BeiBangAn #28 by metascore · China |
PE10 PE-22-28 10mg * 10 vials | 10 × 10 mg = 100 mg | $65.00 $6.50 per vial |
$0.650 | Buy | |
Uther #62 by metascore · China |
Metascore 79Finnrick 64%Bought vials 105% of label · 73 testsTitrateLabNo report for thisOnline checkout |
PE-22-28 10mg (10 Vials / Kit) | 10 × 10 mg = 100 mg | $80.00 $8.00 per vial |
$0.800 | Buy |
Shanghai Wibson Biotechnology WBS #263 by metascore · China |
PE-22-28 10mg*10vials (China warehouse) [jinjier] | 10 × 10 mg = 100 mg | $80.00 $8.00 per vial |
$0.800 | Buy | |
Shanghai Wibson Biotechnology WBS #263 by metascore · China |
PE-22-28 10mg*10vials (US Warehouse 02) [jinjier] | 10 × 10 mg = 100 mg | $90.00 $9.00 per vial |
$0.900 | Buy | |
Hangzhou Youngpeptide Biotechnology HYB #153 by metascore |
PE-22-28 10 mg – 10 Vials | 10 × 10 mg = 100 mg | $95.00 $9.50 per vial |
$0.950 | Buy | |
Shanghai Wibson Biotechnology WBS #263 by metascore · China |
PE-22-28 10mg*10vials (China warehouse) [wbspeptide.com] | 10 × 10 mg = 100 mg | $105.00 $10.50 per vial |
$1.05 | Buy | |
Shanghai Wibson Biotechnology WBS #263 by metascore · China |
PE-22-28 10mg*10vials (US Warehouse 02) [wbspeptide.com] | 10 × 10 mg = 100 mg | $120.00 $12.00 per vial |
$1.20 | Buy | |
Qingdao Sigma Chemical QSC #69 by metascore |
PE-22-28 10mg | 20-Vial Kit | Progerin-Targeting | 20 × 10 mg = 200 mg | $370.00 $18.50 per vial |
$1.85 | Buy | |
Qingdao Sigma Chemical QSC #69 by metascore |
PE-22-28 10mg | 10-Vial Kit | Progerin-Targeting | 10 × 10 mg = 100 mg | $210.00 $21.00 per vial |
$2.10 | Buy | |
Peptagon #31 by metascore |
Metascore 82 medium confidenceFinnrick UnratedBought vials 102% of label · 3 testsTitrateLabNo report for thisConfirmed with lab: 38 of 38Online checkout |
PE-22-28 Research Peptide – 10mg | 1 × 10 mg | $32.00 | $3.20 | Buy |
Eros Peptides #129 by metascore · US, GA 30339 |
Metascore 74 medium confidenceFinnrick 77%Bought vials 110% of label · 3 testsTitrateLab · Peptide CriticNo report for thisOnline checkout |
PE-22-28 10MG | 1 × 10 mg | $33.99 | $3.40 | Buy |
Polaris Peptides #20 by metascore · US? |
Metascore 84Finnrick 63%Bought vials 110% of label · 99 testsTitrateLab · PeptideBase · PeptideCheckedNo report for thisOnline checkout |
PE 22-28 13mg | 1 × 13 mg | $45.00 | $3.46 | Buy |
Gulf Coast Aminos #17 by metascore |
Metascore 85 medium confidenceFinnrick 81%Bought vials 109% of label · 3 testsTitrateLabLab 99.7% pure · 93% of labelAccount needed |
PE-22-28 10mg | 1 × 10 mg | $34.95 | $3.50 | Buy |
Ion Peptide #4 by metascore |
Metascore 87 medium confidenceFinnrick 82%Bought vials 108% of label · 4 testsTitrateLab · PeptideBase · Peptide CriticNo report for thisConfirmed with lab: 40 of 40Online checkout |
PE-22-28 – 10mg | 1 × 10 mg | $36.75 | $3.68 | Buy |
Bio Pepz #98 by metascore · US |
Metascore 76 medium confidenceFinnrick 82%Bought vials 110% of label · 4 testsTitrateLabNo report for thisAccount needed |
PE 22-28 10MG | 1 × 10 mg | $40.00 | $4.00 | Buy |
Bulk Peptide Wholesale #29 by metascore |
Metascore 82 medium confidenceFinnrick 68%Bought vials 103% of label · 7 testsTitrateLab · PeptideBaseNo report for thisOnline checkout |
PE-22-28 5mg (10 vials) | 10 × 5 mg = 50 mg | $200.00 $20.00 per vial |
$4.00 | Buy |
Lab Rat Peptide #206 by metascore · US |
PE-22-28 10MG | 1 × 10 mg | $45.99 | $4.60 | Buy | |
Pure Peptide Labs #53 by metascore · US |
Metascore 79 medium confidenceFinnrick 63%PepIndex 23/100Bought vials 102% of label · 4 testsTitrateLab · PeptideBase · Peptide CriticNo report for thisOnline checkout |
PE-22-28 10 mg | 1 × 10 mg | $49.95 | $5.00 | Buy |
Peptidology #5 by metascore · US, AZ 85254 |
Metascore 87Finnrick 71%Bought vials 97% of label · 18 testsTitrateLab · PeptideBase · Peptide Critic · PeptideCheckedNo report for thisConfirmed with lab: 34 of 34Online checkout |
PE 22-28 10 mg (10mg | Batch. 1748) | 1 × 10 mg | $49.99 | $5.00 | Buy |
Amino Usa #136 by metascore · US |
Metascore 74 medium confidenceFinnrick 32%Bought vials 89% of label · 3 testsTitrateLabLab 99.5% pure · 112% of labelAccount needed |
PE-22-28 10mg | 1 × 10 mg | $50.00 | $5.00 | Buy |
Alpha BioMed #281 by metascore · US |
PE-22-28 (10mg) | 1 × 10 mg | $52.00 | $5.20 | Buy | |
Modern Aminos Affiliate #125 by metascore · US |
Metascore 75 medium confidenceFinnrick 79%PepIndex 81/100Bought vials 100% of label · 5 testsTitrateLab · PeptideBase · Peptide CriticNo report for thisOnline checkout |
PE-22-28 10MG $30 off through this site's link (new customers) |
1 × 10 mg | $54.00 $30 off through this site's link (new customers) |
$5.40 | Buy |
Paramount Peptides #133 by metascore · US CA |
Metascore 74Finnrick 64%PepIndex 55/100Bought vials 114% of label · 65 testsTitrateLab · Peptide CriticNo report for thisOnline checkout |
PE-22-28 (10mg) | 1 × 10 mg | $55.25 | $5.53 | Buy |
Tydes #41 by metascore · US: NC |
Metascore 80Finnrick 68%Bought vials 117% of label · 44 testsTitrateLab · Peptide CriticNo report for thisConfirmed with lab: 16 of 16Online checkout |
PE 22-28 8mg | 1 × 8 mg | $49.99 | $6.25 | Buy |
Core Peptides #282 by metascore |
Metascore 70 medium confidenceFinnrick 76%PepIndex 24/100Bought vials 92% of label · 4 testsTitrateLab · PeptideBase · Peptide Critic · PeptideCheckedNo report for thisOnline checkout |
PE-22-28 – 8MG | 1 × 8 mg | $54.00 | $6.75 | Buy |
Atomik Labz Affiliate #85 by metascore · US. Florida, 33411 |
Metascore 77Finnrick 69%Bought vials 112% of label · 44 testsTitrateLab · Peptide CriticNo report for thisOnline checkoutCheck vendor |
PE-22-28 8mg Ten Pack | 10 × 8 mg = 80 mg | $540.00 $54.00 per vial |
$6.75 | Buy |
Orbitrex Peptides #1 by metascore · US |
Metascore 90Finnrick 71%Bought vials 104% of label · 27 testsTitrateLab · PeptideBase · Peptide CriticLab 99.8% pure · 116% of labelOnline checkout |
PE-22-28 10mg | 1 × 10 mg | $69.99 | $7.00 | Buy |
Simple Peptide #25 by metascore · US, FL 33446 |
Metascore 83Finnrick 62%PepIndex 82/100Bought vials 100% of label · 44 testsTitrateLabNo report for thisOnline checkout |
PE-22-28 10mg | 1 × 10 mg | $72.00 | $7.20 | Buy |
Amino Asylum #245 by metascore |
Metascore 71Finnrick 62%PepIndex 26/100Bought vials 100% of label · 15 testsTitrateLab · PeptideBaseNo report for thisOnline checkout |
PE-22-28 10MG | 1 × 10 mg | $74.99 | $7.50 | Buy |
Peptide Group Buy PGB #39 by metascore · US |
PE22-28 8mg | 1 × 8 mg | $60.00 | $7.50 | Buy | |
Atomik Labz Affiliate #85 by metascore · US. Florida, 33411 |
Metascore 77Finnrick 69%Bought vials 112% of label · 44 testsTitrateLab · Peptide CriticNo report for thisOnline checkoutCheck vendor |
PE-22-28 8mg | 1 × 8 mg | $60.00 | $7.50 | Buy |
Mixing a 10 mg vial
What each common amount of bacteriostatic water gives you on a U-100 insulin syringe. Pick a vial size above to change it.
| Water | Strength | Per 10 units (0.1 mL) | Per unit |
|---|---|---|---|
| 1 mL | 10 mg/mL | 1,000 mcg | 100 mcg |
| 2 mL | 5 mg/mL | 500 mcg | 50 mcg |
| 3 mL | 3.333 mg/mL | 333.3 mcg | 33.33 mcg |
| 5 mL | 2 mg/mL | 200 mcg | 20 mcg |
Published lab results
6 certificates of analysis that vendors publish for PE-22-28. Numbers are only filled in where the document is readable text; image-only COAs are linked without numbers. A vendor's own COA shows one tested sample, not every batch.
| Vendor | Lab | Date | Label | Measured | Purity | Batch | |
|---|---|---|---|---|---|---|---|
Gulf Coast Aminos |
Freedom Diagnostics | 2026-09-25 | 10 mg | 9.29 mg 93% | 99.72% | PE2-10-0926 | View |
Amino Usa |
BioRegen | 2026-09-10 | 10 mg | 11.18 mg 112% | 99.49% | 26PE10-0004 | View |
Peptide Group Buy PGB |
Janoshik | 2026-09-07 | 8 mg | 8.92 mg 112% | 99.82% | PSPE2208-1 (Round 1) | View |
NuLife PeptidesCOA note |
Freedom Diagnostics | 2026-09-01 | 10 mg | 8.91 mg 89% | 99.63% | NLPE10501 (FD #2608280262, client 'Wholesale', 'PE-22-28 10mg') | View |
Orbitrex Peptides |
Freedom Diagnostics | 2026-07-25 | 10 mg | 11.61 mg 116% | 99.76% | PE10826 | View |
Cocer Peptides |
Janoshik | – | 10 mg | – | – | CS-pe10-821 | View (image) |
Doses studied in research Animal or lab studies only
What was given to people (or animals) in published studies and official labels, each linked to its source. This is not a recommendation: study products, purity and supervision differ from research-grade vials.
Animal studies: PE-22-28 was tested in cells (TREK-1 channel IC50 about 0.12 nM) and in mouse depression models with 4-day sub-chronic treatment; a related shortened spadin analogue ('mini-spadin') was given intraperitoneally to mice at 0.03 μg/kg daily for 7 days after stroke or 3 μg/kg 4 days per week.
No human studies of PE-22-28 exist. Doses in animal studies do not translate directly to people. Not approved by FDA or EMA.
What the research says
PE-22-28 is a 7-amino-acid fragment of the antidepressant peptide spadin; only one paper directly characterizes it (in cells and mice), with related work on the spadin analog 'mini-spadin' and a review of shortened spadin analogs. There are no human studies.
Key papers ✓ 4
-
Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity.Humans + animals4-day sub-chronic treatmentIn vitro patch-clamp plus in vivo mouse behavioral tests (forced swimming, novelty suppressed feeding) of PE 22-28 and derivatives
PE 22-28 blocked TREK-1 channels more potently than spadin (IC50 0.12 nM vs 40–60 nM), reduced immobility in mouse depression tests, induced neurogenesis after 4 days and lasted up to 23 h vs 7 h for spadin.
Key resultIC50 0.12 nM for PE 22-28 vs 40-60 nM for spadin; action duration up to 23 h instead of 7 h
Study details
- Studied
- hTREK-1/HEK cells and mice (behavioral models of depression, cortical neurons)
- Compared with
- Spadin
- Main outcome
- TREK-1 inhibition, immobility time, latency to eat, neurogenesis, duration of action
- Authors' conclusion
- PE 22-28 and its derivatives are promising alternatives to spadin for treating depression, with better TREK-1 affinity, antidepressant-like activity in mice and longer duration.
- Limitations
- Mouse and cell study; no human data.
-
First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides.Animalssize not reported7 days of low dose, then higher dose 4 days/week until sacrificeMini-spadin (0.03 micrograms/kg early, then 3 micrograms/kg) injected intraperitoneally; electrophysiology and behavioral tests
In a mouse stroke model, mini-spadin (a shortened spadin analogue) improved motor and cognitive deficits and prevented post-stroke depression-like behaviour.
Study details
- Studied
- Mice with focal ischemia and post-stroke depression
- Main outcome
- Motor and cognitive deficits, dopaminergic degeneration, post-stroke depression (forced swim, novelty suppressed feeding)
- Authors' conclusion
- Mini-spadin improved stroke deficits and prevented post-stroke depression in mice, with enhanced neurogenesis and synaptogenesis; the authors call this the first evidence that TREK-1 modulation may be protective.
- Limitations
- Mouse model; mini-spadin is a spadin analog, not PE 22-28 itself.
-
Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway.Cells / labIn vitro biochemical, imaging and cell biology experiments with PE, Spadin and Mini-Spadin
Sortilin propeptide derivatives spadin and mini-spadin protected pancreatic beta cells from cytokine-induced death; mini-spadin promoted beta-cell proliferation.
Study details
- Studied
- Pancreatic beta-cells exposed to Interleukin-1beta
- Main outcome
- Beta-cell survival, CaM-Kinase/CREB signaling, proliferation
- Authors' conclusion
- PE and derivatives protected beta-cells against cytokine-induced death via CaM-Kinase and CREB, and Mini-Spadin promoted proliferation, suggesting possible roles against diabetes.
- Limitations
- In vitro cell study.
-
Fighting against depression with TREK-1 blockers: Past and future. A focus on spadin.No new dataNarrative review
Review by the developing group summarizing spadin and its shortened analogs as fast-acting TREK-1-blocking antidepressant candidates in rodents.
Study details
- Main outcome
- Development of spadin and shortened analogs as TREK-1 blocking antidepressants
- Authors' conclusion
- Spadin acts within 4 days, and shortened analogs show increased TREK-1 inhibition, improved antidepressant activity and longer bioavailability than spadin, which is stable for less than 7 h in vivo.
- Limitations
- Review; supporting data are preclinical.
Reported side effects
No human safety data in the published literature.
✓ positive · ✗ negative · ~ mixed · ? inconclusive, judged on each paper's own main outcome. Grades: A strong human evidence → D little or none. Papers and verdicts are drawn from PubMed, Europe PMC and Russian journals (CyberLeninka); not medical advice.
Discussions elsewhere
Experiences and questions about PE-22-28 on other sites. Treat anecdotes with care.
PE-22-28: questions people ask
What is PE-22-28?
TREK-1 inhibitor peptide (spadin analog). A shortened version of the peptide spadin that blocks the TREK-1 potassium channel; showed fast antidepressant-like effects in mice.
How much does PE-22-28 cost?
The cheapest PE-22-28 from an independently tested vendor is $0.650 per mg (Andy Peps Studio, PE10 PE-22-28 10mg * 10 vials, $65.00). Across 34 listings from 29 vendors the median is $4.00 per mg.
Where can I buy PE-22-28?
29 vendors tested by Finnrick sell PE-22-28. The cheapest per mg right now: Andy Peps Studio ($0.650), Baohua Dongnuo Biotechnology BHD ($0.650), LN Peptides ($0.650). 4 of them publish a lab report (COA) for PE-22-28; compare lab scores and reports in the table above before buying.
How much bacteriostatic water for 10 mg of PE-22-28?
Adding 2 mL of bacteriostatic water to a 10 mg vial of PE-22-28 gives 5 mg/mL: each 10 units on a U-100 insulin syringe holds 500 mcg. With 1 mL it's 10 mg/mL (1,000 mcg per 10 units); with 3 mL, 3.333 mg/mL (333.3 mcg per 10 units). More water makes small amounts easier to measure. Mixing charts: 8 mg, 10 mg.
Is PE-22-28 FDA approved?
Not approved. Research use only.
Can PE-22-28 be compounded in the US?
Not an FDA-approved drug and not nominated for FDA's 503A bulks list, so US pharmacies can't legally compound it. Compounding status for every peptide.
Does PE-22-28 work? What does the research say?
Evidence grade D (little or no evidence), from 4 papers: Only one paper tests PE-22-28 itself (cells and mice); other work concerns spadin and mini-spadin, different analogues. PE-22-28 is a 7-amino-acid fragment of the antidepressant peptide spadin; only one paper directly characterizes it (in cells and mice), with related work on the spadin analog 'mini-spadin' and a review of shortened spadin analogs. There are no human studies. See the papers.
What dose of PE-22-28 was used in studies?
PE-22-28 is tested only in animals or cells. PE-22-28 was tested in cells (TREK-1 channel IC50 about 0.12 nM) and in mouse depression models with 4-day sub-chronic treatment; a related shortened spadin analogue ('mini-spadin') was given intraperitoneally to mice at 0.03 μg/kg daily for 7 days after stroke or 3 μg/kg 4 days per week. These are amounts used in published studies or official labels, not a recommendation.